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Effects of pristine or contaminated polyethylene microplastics on zebrafish development

2022Journal article Open access
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dc.contributor.authorTarasco, Marco
dc.contributor.authorGavaia, Paulo
dc.contributor.authorBensimon-Brito, Anabela
dc.contributor.authorCordelières, Fabrice P.
dc.contributor.authorSantos, Tamara
dc.contributor.authorMartins, Gil
dc.contributor.authorDe Castro, Daniela
dc.contributor.authorSilva, Nadia
dc.contributor.authorCabrita, Elsa
dc.contributor.authorBebianno, Maria
dc.contributor.authorStainier, Didier Y.R.
dc.contributor.authorCancela, M. Leonor
dc.contributor.authorLaizé, Vincent
dc.date.accessioned2022-12-19T10:30:10Z
dc.date.available2022-12-19T10:30:10Z
dc.date.issued2022
dc.description.abstractThe presence of microplastics in the aquatic ecosystem represents a major issue for the environment and human health. The capacity of organic pollutants to adsorb onto microplastic particles raises additional concerns, as it creates a new route for toxic compounds to enter the food web. Current knowledge on the impact of pristine and/or contaminated microplastics on aquatic organisms remains insufficient, and we provide here new insights by evaluating their biological effects in zebrafish (Danio rerio). Zebrafish larvae were raised in ZEB316 stand-alone housing systems and chronically exposed throughout their development to polyethylene particles of 20-27 mu m, pristine (MP) or spiked with benzo[alpha]pyrene (MP-BaP), supplemented at 1% w/w in the fish diet. While they had no effect at 30 days post-fertilization (dpf), MP and MP-BaP affected growth parameters at 90 and 360 dpf. Relative fecundity, egg morphology, and yolk area were also impaired in zebrafish fed MP-BaP. Zebrafish exposed to experimental diets exhibited an increased incidence of skeletal deformities at 30 dpf as well as an impaired development of caudal fin/scales, and a decreased bone quality at 90 dpf. An intergenerational bone formation impairment was also observed in the offspring of parents exposed to MP or MP-BaP through a reduction of the opercular bone in 6 dpf larvae. Beside a clear effect on bone development, histological analysis of the gut revealed a reduced number of goblet cells in zebrafish fed MP-BaP diet, a sign of intestinal inflam-mation. Finally, exposure of larvae to MP-BaP up-regulated the expression of genes associated with the BaP response pathway, while negatively impacting the expression of genes involved in oxidative stress. Altogether, these data suggest that long-term exposure to pristine/contaminated microplastics not only jeopardizes fish growth, reproduction performance, and skeletal health, but also causes intergenerational effects.pt_PT
dc.description.sponsorshipEMBRC. PT ALG-01-0145-FEDER022121; CA15124; ANR-10-INBS-04
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.chemosphere.2022.135198pt_PT
dc.identifier.issn0045-6535
dc.identifier.urihttp://hdl.handle.net/10400.1/18655
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationLA/P/0101/2020
dc.relationAlgarve Centre for Marine Sciences
dc.relationCentre for Marine and Environmental Research (CIMA)
dc.relationAlgarve Centre for Marine Sciences
dc.relationHow microplastics and adsorbed pollutants affect zebrafish development
dc.relationHow microplastics and adsorbed pollutants affect zebrafish development
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectMicroplasticspt_PT
dc.subjectPolyethylenept_PT
dc.subjectBenzo[α]pyrenept_PT
dc.subjectZebrafishpt_PT
dc.subjectOsteotoxicitypt_PT
dc.subjectReproductionpt_PT
dc.subjectDevelopmentpt_PT
dc.subjectIntergenerational effectpt_PT
dc.titleEffects of pristine or contaminated polyethylene microplastics on zebrafish developmentpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleCentre for Marine and Environmental Research (CIMA)
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleHow microplastics and adsorbed pollutants affect zebrafish development
oaire.awardTitleHow microplastics and adsorbed pollutants affect zebrafish development
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04326%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00350%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04326%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBD%2F128634%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/COVID%2FBD%2F151848%2F2021/PT
oaire.citation.startPage135198pt_PT
oaire.citation.titleChemospherept_PT
oaire.citation.volume303pt_PT
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person.familyNameTarasco
person.familyNameGavaia
person.familyNameSantos
person.familyNameMartins
person.familyNamede Castro
person.familyNameSilva
person.familyNameCabrita
person.familyNameBebianno
person.familyNameCancela
person.givenNameMarco
person.givenNamePaulo
person.givenNameTamara
person.givenNameGil
person.givenNameDaniela
person.givenNameNádia
person.givenNameElsa
person.givenNameMaria
person.givenNameM. Leonor
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person.identifier.ridG-9575-2017
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person.identifier.scopus-author-id57194105105
person.identifier.scopus-author-id6507104377
person.identifier.scopus-author-id10244362100
person.identifier.scopus-author-id26645697000
person.identifier.scopus-author-id7004152715
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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