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Parallel Genome-wide Profiling of Coding and Non-coding RNAs to Identify Novel Regulatory Elements in Embryonic and Maturated Heart

2018-09Journal article Open access
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dc.contributor.authorSabour, Davood
dc.contributor.authorMachado, Rui
dc.contributor.authorPinto, José P.
dc.contributor.authorRohani, Susan
dc.contributor.authorSahito, Raja G. A.
dc.contributor.authorHescheler, Jurgen
dc.contributor.authorFutschik, Matthias
dc.contributor.authorSachinidis, Agapios
dc.date.accessioned2018-12-07T14:58:11Z
dc.date.available2018-12-07T14:58:11Z
dc.date.issued2018-09
dc.description.abstractHeart development is a complex process, tightly regulated by numerous molecular mechanisms. Key components of the regulatory network underlying heart development are transcription factors (TFs) and microRNAs (miRNAs), yet limited investigation of the role of miRNAs in heart development has taken place. Here, we report the first parallel genome-wide profiling of polyadenylated RNAs and miRNAs in a developing murine heart. These data enable us to identify dynamic activation or repression of numerous biological processes and signaling pathways. More than 200 miRNAs and 25 long non-coding RNAs were differentially expressed during embryonic heart development compared to the mature heart; most of these had not been previously associated with cardiogenesis. Integrative analysis of expression data and potential regulatory interactions suggested 28 miRNAs as novel regulators of embryonic heart development, representing a considerable expansion of the current repertoire of known cardiac miRNAs. To facilitate follow-up investigations, we constructed HeartMiR (http://heartmir.sysbiolab.eu), an open access database and interactive visualization tool for the study of gene regulation by miRNAs during heart development.
dc.identifier.doi10.1016/j.omtn.2018.04.018
dc.identifier.issn2162-2531
dc.identifier.urihttp://hdl.handle.net/10400.1/11898
dc.language.isoeng
dc.peerreviewedyes
dc.publisherCell Press
dc.relationDEVELOPMENT OF SOFTWARE TOOLS FOR THE PREDICTION OF CELULAR FATE IN STEM CELL DIFERENTIATION
dc.relationDeciphering the gene regulatory networks of cyanobacteria
dc.subjectCirculating Micrornas
dc.subjectCardiac Development
dc.subjectStem-Cells
dc.subjectIn-Vivo
dc.subjectCardiovascular-Diseases
dc.subjectGene
dc.subjectCardiomyocytes
dc.subjectMorphogenesis
dc.subjectCardiogenesis
dc.subjectTargets
dc.titleParallel Genome-wide Profiling of Coding and Non-coding RNAs to Identify Novel Regulatory Elements in Embryonic and Maturated Heart
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleDEVELOPMENT OF SOFTWARE TOOLS FOR THE PREDICTION OF CELULAR FATE IN STEM CELL DIFERENTIATION
oaire.awardTitleDeciphering the gene regulatory networks of cyanobacteria
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FBIM%2F04773%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04326%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F96890%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Investigador FCT/IF%2F00881%2F2013%2FCP1198%2FCT0001/PT
oaire.citation.endPage173
oaire.citation.startPage158
oaire.citation.titleMolecular Therapy-Nucleic Acids
oaire.citation.volume12
oaire.fundingStream5876
oaire.fundingStream5876
oaire.fundingStreamInvestigador FCT
person.familyNameMachado
person.familyNameFutschik
person.givenNameRui
person.givenNameMatthias
person.identifier.ciencia-id5D19-8F5F-3CE1
person.identifier.ciencia-idA71B-AD01-3501
person.identifier.orcid0000-0002-4080-2353
person.identifier.orcid0000-0002-6245-8071
person.identifier.scopus-author-id55991033900
person.identifier.scopus-author-id14017989400
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
rcaap.typearticle
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