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Polyoxovanadates with emerging biomedical activities

2021-11Journal article Open access
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dc.contributor.authorAureliano, Manuel
dc.contributor.authorGumerova, Nadiia I.
dc.contributor.authorSciortino, Giuseppe
dc.contributor.authorGarribba, Eugenio
dc.contributor.authorRompel, Annette
dc.contributor.authorCrans, Debbie C.
dc.date.accessioned2021-09-14T08:29:46Z
dc.date.available2021-09-14T08:29:46Z
dc.date.issued2021-11
dc.description.abstractPolyoxovanadates (POVs) are a subclass of a larger family of polyanionic group V and VI metal-oxo clus ters that are known as polyoxometalates (POMs). POMs have been found to have antidiabetic, antibacte rial, antiprotozoal, antiviral and anticancer activities, which have sparked interest in their use as bioinorganic drugs. Among POVs, decavanadate ([V10O28] 6 ; V10) is an isopolyoxovanadate recently described to have several medicinal applications. In the present review, recent insights into POVs with emergent anticancer, antimicrobial and antiviral applications are described. Additionally, POVs’ stability and speciation under experimental biological conditions as well as POVs (in particular, V10) in vivo and ex vivo effects are highlighted. Finally, we report the most important 21st century studies of POVs’ effects and/or targets against cancer, bacteria and viruses including: apoptosis, cell cycle arrest, interference with ions transport system, inhibition of mRNA synthesis, cell morphology changes, changes in metabolic pathways, phosphorylase enzyme inhibition and cell signaling, formation of reactive oxygen species, lipid peroxidation, inhibition of viral mRNA polymerase, inhibition of virus binding to the host cell, penetra tion and interaction with virus protein cages.pt_PT
dc.description.sponsorshipRASSR79857, FJC2019-039135-I, P33927, P33089pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.ccr.2021.214143pt_PT
dc.identifier.eissn1873-3840
dc.identifier.urihttp://hdl.handle.net/10400.1/17097
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectPolyoxovanadatespt_PT
dc.subjectPolyoxometalatept_PT
dc.subjectDecavanadatept_PT
dc.subjectVanadatept_PT
dc.subjectMetal-oxides speciationpt_PT
dc.subjectAnticancer drugpt_PT
dc.subjectAntimicrobial drugpt_PT
dc.subjectAntiviral drugpt_PT
dc.titlePolyoxovanadates with emerging biomedical activitiespt_PT
dc.title.alternativePolioxovanadates com atividades biomédicas emergentespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/157544/PT
oaire.citation.startPage214143pt_PT
oaire.citation.titleCoordination Chemistry Reviewspt_PT
oaire.citation.volume447pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameAureliano
person.givenNameManuel
person.identifier584146
person.identifier.ciencia-idAA14-3490-DC5E
person.identifier.orcid0000-0003-4858-3201
person.identifier.ridI-3283-2012
person.identifier.scopus-author-id6603412860
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication.latestForDiscoverybb413661-7edd-4b57-8338-33889cfd05db
relation.isProjectOfPublicationb4215d8c-d780-4b2e-ae38-d55a36db9755
relation.isProjectOfPublication.latestForDiscoveryb4215d8c-d780-4b2e-ae38-d55a36db9755

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