Hemolytic uremic syndrome in children: a case report

Ling, T.; Loureiro, A.; Silva, M. J.

http://hdl.handle.net/10400.1/26317

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Authors

Ling, T.

Loureiro, A.

Silva, M. J.

Abstract(s)

The Hemolytic Uremic Syndrome (HUS) is characterized by the simultaneous occurrence of microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury, caused by microvascular thrombosis. HUS can be classified as acquired or hereditary according to its pathophysiology. The main cause of acquired HUS are infections caused by Shiga toxin-producing Escherichia coli infections (STEC-HUS), while hereditary HUS is mainly caused by complement factors gene mutations. Worldwide incidence of HUS is estimated to be 2-3 cases per 100.000 children, of which 90% are STEC-HUS.