ULS_10.2-MED-ConferĂȘncias
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- Asdas responses in patients with axial spondyloarthritis starting bdmards: results from a multicentre prospective cohortPublication . Santos, M. E.; Ramiro, S.; Van der Heijde, D.; LandewĂ©, R.; Santos, F. Pimentel; Machado, A. R. Cruz; Ferreira, C.; Gomes, C.; Soares, C. Dantas; Miguel, C.; Albuquerque, F.; Martins, F.; Silva, L.; Santos, H.; Almeida, I.; Bernardes, M.; Khmelinskii, N.; Valente, P.; Teixeira, P. M.; Matias, S. EmĂdio; Fraga, V.; Branco, J. C.; Sepriano, A.ASAS and EULAR recommend the use of an improvement â„1.1 in ASDAS at 12 weeks to determine the continuation of a bDMARD. However, it is debated whether improvements can occur and whether patientsâ characteristics influence (time to) response.
- Pre-operative exposure to tofacitinib is as safe as biologics in patients with ulcerative colitis undergoing colectomy: a multicentre observational studyPublication . Dragoni, G.; Innocenti, T.; Amiot, A.; Castiglione, F.; Melotti, L.; Festa, S.; Savarino, E. V.; Truyens, M.; Argyriou, K.; Noviello, D.; Molnar, T.; Bouillon, V.; Bezzio, C.; Eder, P.; Fernandes, S.; Kagramanova, A.; Armuzzi, A.; Oliveira, R.; Viola, A.; Ribaldone, D. G.; Drygiannakis, I.; ViganĂČ, C.; Calella, F.; Gravina, A. G.; Pugliese, D.; Chaparro, M.; Ellul, P.; Vieujean, S.; Milla, M.; Caprioli, F.Patients with ulcerative colitis (UC) receiving immunomodulators are at substantial risk of colectomy. Since robust evidence regarding the post-operative outcomes of patients treated with anti-JAKs in the pre-operative phase is lacking, we aimed to assess the risk of complications of tofacitinib exposure prior to colectomy in comparison with anti-TNFs, vedolizumab, and ustekinumab.
- Retro tIming: A multicentric retrospective analysis of immunotherapy timing in metastatic melanomaPublication . Gonçalves, Lisa; Goncalves, Duarte; Casanelles, Teresa Esteban; Guerra, Laura Pratas; Menezes, Maria B.; Branco, Vanessa Duarte; LuĂs, Joana Alves; SimĂ”es, Filipa; Gramaça, JoĂŁo; Pinho, InĂȘs S.; Barroso, Tiago; Patel, Vanessa; Martins, Miguel Esperança; BrĂĄs, Raquel Lopes; Sousa, Rita Teixeira de; Mansinho, AndrĂ©; Torres, Sofia; Costa, LuisImmune checkpoint inhibitors (ICI) targeting programmed cell death protein 1 (PD-1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) are now the standard of care in the treatment of metastatic melanoma (mM). The interplay between cancer cells and tumor microenvironment cells (e.g. immune cells) impacts cancer cell survival, local invasion, and metastatic dissemination. Chrono-immunotherapy is an emerging field as circadian oscillations are observed in the immune landscape (e.g immune cell numbers) as well as in the expression of immunotherapy targets (e.g. PD-1).
- 313P Disease and treatment patterns for advanced cholangiocarcinoma: A multicentric study from PortugalPublication . Gonçalves, J. C. N.; Freitas, A. R. R.; Fortuna, A. R.; Menezes, M. B.; Gramaça, J.; Fernandes, I. C. Gomes; Ăngelo, I. C.; Trabulo, C. F. P.; Sousa, C. Xavier de; Pina, I. M. MatosGemcitabine plus cisplatin (GC) was standard first-line treatment for advanced biliary tract cancers until recently, supported by the UK ABC-02 study. However, TOPAZ-1 showed survival improvement with Durvalumab plus GC. Nevertheless, a significant proportion of patients face challenges with GC tolerability, prompting into alternatives such as gemcitabine and carboplatin (GCb). Moreover, there remains a paucity of stratified data pertaining to cholangiocarcinomas (CCA). We analyzed 5-year trends to determine treatment rates and cisplatin use in the real world.
- Clinical characteristics and outcomes of PTLD after kidney transplant: a single center experiencePublication . Afonso, Rita; Nicolau, Carla; Vieira, Miguel Bigotte; Caeiro, Fernando; Jorge, CristinaPost-Transplant Lymphoproliferative Disorder (PTLD) is a serious and potentially fatal complication of immunosuppression in kidney transplantation. Given the rarity of this entity, a high index of suspicion is necessary. We aimed to review the incidence, clinical presentation, histological subtypes, treatment, patient and graft survival of PTLD in kidney transplant patients in our unit.
- Enhancing primary prevention: the incremental predictive value of high-sensitivity cardiac troponin T beyond ASCVD risk assessmentPublication . Andraz, S.; Pereira, J. Massa; Costa, H.; Espirito Santo, M.; Hamann, L.; Fernandes, R.; Bispo, J.; Carvalho, D.; Bento, D.; Azevedo, P.; Mimoso, J.Atherosclerotic cardiovascular disease (ASCVD) is a global health challenge, prompting widespread use of conventional risk assessment tools (SCORE2 in Europe and the ASCVD Risk calculator in the United States) to guide preventive strategies. Emerging evidence indicates that high-sensitivity cardiac troponin (hsTn) may refine risk stratification.
- Characterization of Clostridioides strains and antibiotic resistance profile in Inflammatory Bowel Disease patients with Clostridioides infectionPublication . Oliveira, R.; Sousa, H. Tavares de; Roseira, J.There is an increasing incidence of community-acquired Clostridioides difficile infection (CDI), particularly in IBD. Due to a suspected community outbreak in mid-2023, we aimed to investigate the microbiological and antibiotic resistance profile of CDI in an IBD cohort, employing blind central reading, in order to better understand its epidemiology.
- Chlamydia trachomatis and Neisseria gonorrhoeae detection: Comparing the recommended detection methods and the ones used in a regional hospital laboratoryPublication . Ling, T.; Pereira, A.; Loureiro, A.; Silva, M. J.Sexually Transmitted Infections (STI) are a group of infections that spread primarily through unprotected sexual contact and can cause serious consequences if not treated. STIs continue to be a significant public health issue with a direct impact in the sexual health of millions of people worldwide.
- Vitamin and micronutrient excess in patients with Crohnâs disease under oral ambulatory exclusive enteral nutritionPublication . Oliveira, R.; Mendes, B.; Neves, J. Cunha; Amorim, E.; Roseira, J.; Sousa, H. Tavares deExclusive enteral nutrition (EEN) is recommended for preoperative nutritional optimization (PNO) in adult Crohn's disease (CD) patients. However, during ambulatory oral EEN, a lack of routine monitoring for vitamins may occur, with a potential risk of hypervitaminosisrelated toxicity, which remains unexplored. This study aims to assess the serum levels of vitamins and micronutrients in CD patients undergoing EEN and to examine its potential impact.
- Chlamydia trachomatis and Neisseria gonorrhoeae detection: Comparing the recommended detection methods and the ones used in a regional hospital laboratoryPublication . Ling, T.; Pereira, A.; Loureiro, A.; Silva, M. J.Sexually Transmitted Infections (STI) are a group of infections that spread primarily through unprotected sexual contact and can cause serious consequences if not treated. STIs continue to be a significant public health issue with a direct impact in the sexual health of millions of people worldwide.