ULS_10.2-MED-ConferĂȘncias
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- A long-term survivors of glioblastoma: a single-centre retrospective studyPublication . Fortuna, A.; Luz, P.; Cordeiro, M.Glioblastoma (GBM) is the most common primary malignant brain tumor in adults, yet, despite advancements in understanding its biology, it remains an incurable disease with a high mortality rate. Less than 5% of patients survive beyond 5 years, making identification of factors associated with long-term survival critical in improving outcomes for patients with glioblastoma.
- Outcomes of diabetic patients with acute coronary syndromes treated with aspirin in primary preventionPublication . Costa, H.; Espirito Santo, M.; Fernandes, R.; Carvalho, D.; Bispo, J.; Guedes, J.; Azevedo, P.; Vinhas, H.; Mimoso, J.; Jesus, I.The use of aspirin in primary prevention (PP) remains a matter of international debate. In type 2 diabetes mellitus (DM2) patients with high/very high cardiovascular (CV) risk, low dose aspirin may be considered for PP (class IIb, evidence level A) in european guidelines in the absence of hemorrhagic contraindication.
- Calcium/magnesium ratio in patients with diabetes and chronic kidney disease: a risk factor for cardiovascular diseasePublication . Borges, Henrique; Afonso, Rita; Marques, Roberto Calças; Jerónimo, Teresa; Silva, AnaChronic Kidney Disease (CKD) and Diabetes Mellitus (DM) are significant risk factors for Cardiovascular (CV) Disease. Patients with CKD and/or DM exhibit higher incidence and prevalence of CV events compared to the general population. Hypomagnesemia and elevated calcium-magnesium (Ca:Mg) ratios have been identified as independent risk factors for CV-related deaths. The aim of this study is to determine the relationship between Ca:Mg and the prognosis of CV disease in patients with CKD and DM.
- Improving vector-borne disease control in AlbufeiraPublication . SĂĄ, R.; Dinis, V.; Edmundo, A.; Costa, I. Carvalho; Figueiredo, V.; Almeida, S.; Fonseca, A.; Lopes, C.; Rodrigues, V.; Correia, M.The Albufeira Health Centre (CSA) comprises various functional units within primary healthcare. Recognizing the limited awareness of colleagues regarding the Vector Surveillance Network (REVIVE), responsible for entomological surveillance of mosquitoes, ticks, and sandflies, the Public Health Unit (USP) initiated a project to improve coordination and knowledge sharing. Implemented in April 2023, the project involved a multidisciplinary team. Informational materials on vector surveillance and control, clinical guidance for common vector-borne diseases (VBDs), tick collection protocols, and specimen registration forms were distributed. A video highlighting entomological surveillance and strategies for prevention and control was disseminated. To date, the project has recorded 45 views of the video (51%). A questionnaire distributed among the target population revealed that only 20% had knowledge of the epidemiological importance of vectors in the Algarve region. None were familiar with REVIVE or its work. Furthermore, participants were not acquainted with the Aedes albopictus mosquito species. Regarding ticks, 20% felt confident in tick removal, but none were aware of the tick genera in the Algarve region. Only 20% were aware of notifiable vector-borne diseases through SINAVE. Training sessions on this topic were suggested. The project emphasized the significance of communication and collaboration among healthcare professionals in the prevention and control of vector-borne diseases. It highlighted the need for continuous education on VBDs, surveillance techniques, and control measures. This innovative project can serve as a model for healthcare centres and countries, contributing to global efforts to improve the response to vector-borne diseases. The project's outreach extended to the Municipal Albufeira Animal Welfare Centre. A new questionnaire will be distributed to gather additional insights and enhance the impact of the project.
- Asdas responses in patients with axial spondyloarthritis starting bdmards: results from a multicentre prospective cohortPublication . Santos, M. E.; Ramiro, S.; Van der Heijde, D.; LandewĂ©, R.; Santos, F. Pimentel; Machado, A. R. Cruz; Ferreira, C.; Gomes, C.; Soares, C. Dantas; Miguel, C.; Albuquerque, F.; Martins, F.; Silva, L.; Santos, H.; Almeida, I.; Bernardes, M.; Khmelinskii, N.; Valente, P.; Teixeira, P. M.; Matias, S. EmĂdio; Fraga, V.; Branco, J. C.; Sepriano, A.ASAS and EULAR recommend the use of an improvement â„1.1 in ASDAS at 12 weeks to determine the continuation of a bDMARD. However, it is debated whether improvements can occur and whether patientsâ characteristics influence (time to) response.
- Pre-operative exposure to tofacitinib is as safe as biologics in patients with ulcerative colitis undergoing colectomy: a multicentre observational studyPublication . Dragoni, G.; Innocenti, T.; Amiot, A.; Castiglione, F.; Melotti, L.; Festa, S.; Savarino, E. V.; Truyens, M.; Argyriou, K.; Noviello, D.; Molnar, T.; Bouillon, V.; Bezzio, C.; Eder, P.; Fernandes, S.; Kagramanova, A.; Armuzzi, A.; Oliveira, R.; Viola, A.; Ribaldone, D. G.; Drygiannakis, I.; ViganĂČ, C.; Calella, F.; Gravina, A. G.; Pugliese, D.; Chaparro, M.; Ellul, P.; Vieujean, S.; Milla, M.; Caprioli, F.Patients with ulcerative colitis (UC) receiving immunomodulators are at substantial risk of colectomy. Since robust evidence regarding the post-operative outcomes of patients treated with anti-JAKs in the pre-operative phase is lacking, we aimed to assess the risk of complications of tofacitinib exposure prior to colectomy in comparison with anti-TNFs, vedolizumab, and ustekinumab.
- Retro tIming: A multicentric retrospective analysis of immunotherapy timing in metastatic melanomaPublication . Gonçalves, Lisa; Goncalves, Duarte; Casanelles, Teresa Esteban; Guerra, Laura Pratas; Menezes, Maria B.; Branco, Vanessa Duarte; LuĂs, Joana Alves; SimĂ”es, Filipa; Gramaça, JoĂŁo; Pinho, InĂȘs S.; Barroso, Tiago; Patel, Vanessa; Martins, Miguel Esperança; BrĂĄs, Raquel Lopes; Sousa, Rita Teixeira de; Mansinho, AndrĂ©; Torres, Sofia; Costa, LuisImmune checkpoint inhibitors (ICI) targeting programmed cell death protein 1 (PD-1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) are now the standard of care in the treatment of metastatic melanoma (mM). The interplay between cancer cells and tumor microenvironment cells (e.g. immune cells) impacts cancer cell survival, local invasion, and metastatic dissemination. Chrono-immunotherapy is an emerging field as circadian oscillations are observed in the immune landscape (e.g immune cell numbers) as well as in the expression of immunotherapy targets (e.g. PD-1).
- 313P Disease and treatment patterns for advanced cholangiocarcinoma: A multicentric study from PortugalPublication . Gonçalves, J. C. N.; Freitas, A. R. R.; Fortuna, A. R.; Menezes, M. B.; Gramaça, J.; Fernandes, I. C. Gomes; Ăngelo, I. C.; Trabulo, C. F. P.; Sousa, C. Xavier de; Pina, I. M. MatosGemcitabine plus cisplatin (GC) was standard first-line treatment for advanced biliary tract cancers until recently, supported by the UK ABC-02 study. However, TOPAZ-1 showed survival improvement with Durvalumab plus GC. Nevertheless, a significant proportion of patients face challenges with GC tolerability, prompting into alternatives such as gemcitabine and carboplatin (GCb). Moreover, there remains a paucity of stratified data pertaining to cholangiocarcinomas (CCA). We analyzed 5-year trends to determine treatment rates and cisplatin use in the real world.
- Clinical characteristics and outcomes of PTLD after kidney transplant: a single center experiencePublication . Afonso, Rita; Nicolau, Carla; Vieira, Miguel Bigotte; Caeiro, Fernando; Jorge, CristinaPost-Transplant Lymphoproliferative Disorder (PTLD) is a serious and potentially fatal complication of immunosuppression in kidney transplantation. Given the rarity of this entity, a high index of suspicion is necessary. We aimed to review the incidence, clinical presentation, histological subtypes, treatment, patient and graft survival of PTLD in kidney transplant patients in our unit.
- Enhancing primary prevention: the incremental predictive value of high-sensitivity cardiac troponin T beyond ASCVD risk assessmentPublication . Andraz, S.; Pereira, J. Massa; Costa, H.; Espirito Santo, M.; Hamann, L.; Fernandes, R.; Bispo, J.; Carvalho, D.; Bento, D.; Azevedo, P.; Mimoso, J.Atherosclerotic cardiovascular disease (ASCVD) is a global health challenge, prompting widespread use of conventional risk assessment tools (SCORE2 in Europe and the ASCVD Risk calculator in the United States) to guide preventive strategies. Emerging evidence indicates that high-sensitivity cardiac troponin (hsTn) may refine risk stratification.