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The biochemistry and regulation of S100A10: a multifunctional plasminogen receptor involved in oncogenesis

2012Journal article Open access
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dc.contributor.authorMadureira, Patricia
dc.contributor.authorO'Connell, Paul A.
dc.contributor.authorSurette, Alexi P.
dc.contributor.authorMiller, Victoria A.
dc.contributor.authorWaisman, David M.
dc.date.accessioned2018-12-07T14:58:31Z
dc.date.available2018-12-07T14:58:31Z
dc.date.issued2012
dc.description.abstractThe plasminogen receptors mediate the production and localization to the cell surface of the broad spectrum proteinase, plasmin. S100A10 is a key regulator of cellular plasmin production and may account for as much as 50% of cellular plasmin generation. In parallel to plasminogen, the plasminogen-binding site on S100A10 is highly conserved from mammals to fish. S100A10 is constitutively expressed in many cells and is also induced by many diverse factors and physiological stimuli including dexamethasone, epidermal growth factor, transforming growth factor-alpha, interferon-gamma, nerve growth factor, keratinocyte growth factor, retinoic acid, and thrombin. Therefore, S100A10 is utilized by cells to regulate plasmin proteolytic activity in response to a wide diversity of physiological stimuli. The expression of the oncogenes, PML-RAR alpha and KRas, also stimulates the levels of S100A10, suggesting a role for S100A10 in pathophysiological processes such as in the oncogenic-mediated increases in plasmin production. The S100A10-null mouse model system has established the critical role that S100A10 plays as a regulator of fibrinolysis and oncogenesis. S100A10 plays two major roles in oncogenesis, first as a regulator of cancer cell invasion and metastasis and secondly as a regulator of the recruitment of tumor-associated cells, such as macrophages, to the tumor site.
dc.description.sponsorshipCanadian Cancer Society Research Institute; Canadian Institutes of Health Research; Foundation for Science and Technology of Portugal
dc.identifier.doi10.1155/2012/353687
dc.identifier.issn1110-7243
dc.identifier.urihttp://hdl.handle.net/10400.1/12063
dc.language.isoeng
dc.peerreviewedyes
dc.publisherHindawi Publishing Corporation
dc.relationWORK PLAN FOR RESEARCH FELLOWSHIP PCOFUND-GA-2009-246542
dc.subjectAnnexin-Ii tetramer
dc.subjectAcute promyelocytic leukemia
dc.subjectCalcium-binding proteins
dc.subjectHuman epithelial-cells
dc.subjectCytosolic Phospholipase A(2)
dc.subjectHuman peripheral monocytes
dc.subjectSite-directed mutagenesis
dc.subjectEf-hand proteins
dc.subjectLight-chain P11
dc.subjectCalpactin-I
dc.titleThe biochemistry and regulation of S100A10: a multifunctional plasminogen receptor involved in oncogenesis
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleWORK PLAN FOR RESEARCH FELLOWSHIP PCOFUND-GA-2009-246542
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBI%2F52182%2F2013/PT
oaire.citation.startPage353687
oaire.citation.titleJournal of Biomedicine and Biotechnology
person.familyNameMadureira
person.givenNamePatricia
person.identifier.ciencia-id6612-9A86-6929
person.identifier.orcid0000-0002-4856-3908
person.identifier.scopus-author-id10340140500
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
rcaap.typearticle
relation.isAuthorOfPublicationa40de6a3-d52d-45dd-8620-cb94a22ebc8f
relation.isAuthorOfPublication.latestForDiscoverya40de6a3-d52d-45dd-8620-cb94a22ebc8f
relation.isProjectOfPublication976621e4-7a18-46a8-af37-c0a4e4b78ca3
relation.isProjectOfPublication.latestForDiscovery976621e4-7a18-46a8-af37-c0a4e4b78ca3

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