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Does non-steroidal anti-inflammatory (NSAID) ibuprofen induce antioxidant stress and endocrine disruption in mussel Mytilus galloprovincialis?

2012Journal article Restricted access
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dc.contributor.authorGonzalez-Rey, Maria
dc.contributor.authorBebianno, Maria João
dc.date.accessioned2020-04-27T10:13:02Z
dc.date.available2020-04-27T10:13:02Z
dc.date.issued2012
dc.description.abstractIbuprofen (IBU) is one of the most sold over-the-counter non-steroidal anti-inflammatory drugs (NSAID) and widely detected in the aquatic ecosystems. Nevertheless, the information regarding IBU effects in biota is still sparse. The goal of this study was to assess IBU potential effect as oxidative stress and endocrine disruption inducer in mussel Mytilus galloprovincialis applying a battery of biomarkers. Over two weeks of exposure to IBU (250 ngL(-1)), superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR), phase II glutathione S-transferase (GST) activities and lipid peroxidation (LPO) levels were determined in the digestive gland and alkali-labile phosphates (ALP) were carried out in sex-differentiated mussels' gonads. The results confirm a transitory induction of antioxidant activities responses concomitant to lipid peroxide formation outline and an increase of ALP levels over time, particularly in exposed males which may lead to mussels' reproductive fitness impairment highlighting a higher impact of IBU as an endocrine disruptor than as a short-term reactive oxygen species (ROS)-generator.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.etap.2011.12.017pt_PT
dc.identifier.issn1382-6689
dc.identifier.urihttp://hdl.handle.net/10400.1/13785
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationEFFECTS OF ACTIVE PHARMACEUTICAL RESIDUES IN MYTILUS GALLOPROVINCIALIS
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAlkaline phosphatasept_PT
dc.subjectAnimalspt_PT
dc.subjectAnti-inflammatory agentspt_PT
dc.subjectAntioxidantspt_PT
dc.subjectBiomarkerspt_PT
dc.subjectCatalasept_PT
dc.subjectDigestive systempt_PT
dc.subjectEndocrine disruptorspt_PT
dc.subjectFemalept_PT
dc.subjectGlutathione reductasept_PT
dc.subjectGlutathione transferasept_PT
dc.subjectGonadspt_PT
dc.subjectIbuprofenpt_PT
dc.subjectLipid peroxidationpt_PT
dc.subjectMalept_PT
dc.subjectMytiluspt_PT
dc.subjectOxidative stresspt_PT
dc.subjectPrincipal component analysispt_PT
dc.subjectSuperoxide dismutasept_PT
dc.subjectTime factorspt_PT
dc.subjectWater Pollutantspt_PT
dc.subjectNon-steroidalpt_PT
dc.titleDoes non-steroidal anti-inflammatory (NSAID) ibuprofen induce antioxidant stress and endocrine disruption in mussel Mytilus galloprovincialis?pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEFFECTS OF ACTIVE PHARMACEUTICAL RESIDUES IN MYTILUS GALLOPROVINCIALIS
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F41606%2F2007/PT
oaire.citation.endPage371pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage361pt_PT
oaire.citation.titleEnvironmental Toxicology and Pharmacologypt_PT
oaire.citation.volume33pt_PT
person.familyNameGonzalez-Rey
person.familyNameBebianno
person.givenNameMaria
person.givenNameMaria
person.identifier.ciencia-id2B11-46AC-B94B
person.identifier.orcid0000-0002-9343-8460
person.identifier.orcid0000-0003-1492-8566
person.identifier.scopus-author-id7004152715
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication2e00a26d-1dd3-4c22-a6bf-ac7943ae0d32
relation.isAuthorOfPublication.latestForDiscovery2e00a26d-1dd3-4c22-a6bf-ac7943ae0d32
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