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Charged pullulan derivatives for the development of nanocarriers by polyelectrolyte complexation

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dc.contributor.authorDionísio, Marita
dc.contributor.authorBraz, L.
dc.contributor.authorCorvo, M.
dc.contributor.authorLourenço, J. P.
dc.contributor.authorGrenha, Ana
dc.contributor.authorCosta, Ana M. Rosa da
dc.date.accessioned2016-06-07T14:44:17Z
dc.date.available2016-06-07T14:44:17Z
dc.date.issued2016
dc.description.abstractPullulan, a neutral polysaccharide, was chemically modified in order to obtain two charged derivatives: reaction with SO3(.)DMF complex afforded a sulfate derivative (SP), while reaction with glycidyltrimethylammonium chloride gave a quaternary ammonium salt (AP). The presence of the charged groups was confirmed by FTIR. Assessment of the positions where the reaction took place was based on (1)H- and (13)C NMR (COSY, HSQC-TOCSY, HSQC-DEPT, and HMBC) experiments. Estimation of the degree of substitution (DS) was made from elemental analysis data, and further confirmed by NMR peak areas in the case of AP. These new derivatives showed the capability to condense with each other, forming nanoparticles with the ability to associate a model protein (BSA) and displaying adequate size for drug delivery applications, therefore making them good candidates for the production of pullulan-based nanocarriers by polyelectrolyte complexation.pt_PT
dc.identifier.doi10.1016/j.ijbiomac.2016.01.054pt_PT
dc.identifier.issn0141-8130
dc.identifier.otherAUT: MDI02044 ;LVB02213; JLO01215; AMG02212;
dc.identifier.urihttp://hdl.handle.net/10400.1/8391
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S0141813016300563pt_PT
dc.subject(3–6): Sulfated pullulanpt_PT
dc.subjectTetraalkylammonium pullulanpt_PT
dc.subjectPolyelectrolyte complexationapt_PT
dc.titleCharged pullulan derivatives for the development of nanocarriers by polyelectrolyte complexationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage138pt_PT
oaire.citation.startPage129pt_PT
oaire.citation.titleInternational Journal of Biological Macromoleculespt_PT
oaire.citation.volume86pt_PT
person.familyNameBraz
person.familyNameLourenço
person.familyNameGrenha
person.familyNameRosa da Costa
person.givenNameLuis
person.givenNameJoão P.
person.givenNameAna
person.givenNameAna M
person.identifier634248
person.identifier305029
person.identifier.ciencia-idBA15-0A43-361F
person.identifier.ciencia-idF81F-A1F0-2A7C
person.identifier.ciencia-id091C-0D58-7225
person.identifier.ciencia-idA418-A85E-5DB1
person.identifier.orcid0000-0002-1500-1976
person.identifier.orcid0000-0002-0501-6672
person.identifier.orcid0000-0002-2136-1396
person.identifier.orcid0000-0003-0225-9537
person.identifier.ridE-1901-2012
person.identifier.ridA-7758-2008
person.identifier.ridH-1392-2017
person.identifier.ridE-2165-2012
person.identifier.scopus-author-id55996112700
person.identifier.scopus-author-id57195730600
person.identifier.scopus-author-id8607930100
person.identifier.scopus-author-id53986075100
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication33ff57b7-7297-41b0-9cdb-acc1cac47463
relation.isAuthorOfPublicationf66ab886-d989-4c1d-9550-527507723c26
relation.isAuthorOfPublication1bd4d8f1-40e5-45af-b1e8-4b8e73a6a70d
relation.isAuthorOfPublication0ca8c16f-6881-4662-bafc-cc51c5ce8d88
relation.isAuthorOfPublication.latestForDiscovery0ca8c16f-6881-4662-bafc-cc51c5ce8d88

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