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A comparative study of the in vitro enzyme inhibitory and antioxidant activities of Butea monosperma (Lam.) Taub. and Sesbania grandiflora (L.) Poiret from Pakistan: New sources of natural products for public health problems

2019-01Journal article Restricted access
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dc.contributor.authorBaessa, M.
dc.contributor.authorRodrigues, Maria João
dc.contributor.authorPereira, Catarina
dc.contributor.authorSantos, T.
dc.contributor.authorNeng, N. da Rosa
dc.contributor.authorNogueira, J. M. F.
dc.contributor.authorBarreira, Luísa
dc.contributor.authorVarela, J.
dc.contributor.authorAhmed, H.
dc.contributor.authorAsif, S.
dc.contributor.authorBoukhari, S. A.
dc.contributor.authorKayani, W. K.
dc.contributor.authorAhmad, Khawaja Shafique
dc.contributor.authorZengin, G.
dc.contributor.authorMollica, A.
dc.contributor.authorCustódio, Luísa
dc.date.accessioned2020-07-24T10:53:25Z
dc.date.available2020-07-24T10:53:25Z
dc.date.issued2019-01
dc.description.abstractInfusions, decoctions and tinctures were prepared from flowers of Butea monosperma (Lam.) Taub. and Sesbania grandiflora (L.) Poiret and evaluated for in vitro inhibition of enzymes implicated on the onset of neurological diseases (acetylcholinesterase: AChE and butyrylcholinesterase: BuChE), diabetes (alpha-glucosidase and alpha-amylase), obesity (lipase) and skin hyperpigmentation (tyrosinase). Extracts were also appraised for radical scavenging activity (RSA) on 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radicals, and for metal chelating activity on copper and iron ions. Samples were evaluated for their total contents in different phenolics groups by spectrophotometric methods, for phenolic profile by high performance liquid chromatography e diode array detection (HPLC-DAD) and for mineral contents by microwave plasma-atomic emission spectrometry (MP-AE). Regarding B. monosperma, the tincture allowed for a moderate inhibition of AChE, the decoction was able to inhibit alpha-glucosidase and no activity was observed towards BuChE, alpha-amylase or lipase. All extracts had a low or moderate inhibition towards tyrosinase, and significant RSA and metal chelating potential. As for S. grandiflora, only the decoction inhibited AChE, none of the extracts was able to inhibit BuChE, all samples inhibited alpha-glucosidase and infusions and decoctions had similar inhibitory properties towards alpha-amylase. None of the extracts was active against lipase, but all were able to inhibit tyrosinase. Extracts had also significant RSA, moderate copper chelation and decoctions had the capacity to chelate iron. The most abundant macroelements in both species were potassium and calcium, while iron was the prevalent microelement, especially in B. monosperma. Both species had significant levels of phenolic compounds, and the main components in decoctions and infusions of B. monosperma were syringic and salicylic acids, while the major compound identified in tinctures was the flavonoid luteolin-7-O-glucoside. In S. grandiflora the most abundant were chlorogenic and neochlorogenic acids and catechin hydrate. Molecular docking studies on the most abundant molecules in S. grandiflora, (+)-catechin, chlorogenic acid and neochlorogenic acid, indicate that these compounds are able to dock to alpha-glucosidase in a similar manner than acarbose. Our results suggest that flowers of both species are a promising source of high value-added compounds with enzyme inhibitory and antioxidant properties. (c) 2018 SAAB. Published by Elsevier B.V. All rights reserved.
dc.description.sponsorshipFoundation for Science and Technology (FCT)Portuguese Foundation for Science and Technology
dc.description.sponsorshipPortuguese National Budget [CCMAR/Multi/04326]
dc.description.sponsorshipFCT Investigator Programme [IF/00049/2012]
dc.description.sponsorshipFCTPortuguese Foundation for Science and Technology [SFRH/BD/94407/2013, SFRH/BD/116604/2016]
dc.identifier.doi10.1016/j.sajb.2018.04.006
dc.identifier.issn0254-6299
dc.identifier.issn1727-9321
dc.identifier.urihttp://hdl.handle.net/10400.1/14491
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.subjectFactor-kappa-B
dc.subjectPhenolic composition
dc.subjectAntimicrobial activity
dc.subjectBiological-activities
dc.subjectOxidative stress
dc.subjectSyringic acid
dc.subjectCell-line
dc.subjectFlowers
dc.subjectProtein
dc.subjectExtracts
dc.titleA comparative study of the in vitro enzyme inhibitory and antioxidant activities of Butea monosperma (Lam.) Taub. and Sesbania grandiflora (L.) Poiret from Pakistan: New sources of natural products for public health problems
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04326%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F94407%2F2013/PT
oaire.citation.endPage156
oaire.citation.startPage146
oaire.citation.titleSouth African Journal of Botany
oaire.citation.volume120
oaire.fundingStream5876
oaire.fundingStreamSFRH
person.familyNameRodrigues
person.familyNameGuerreiro Pereira
person.familyNameBarreira
person.familyNameCustódio
person.givenNameMaria João
person.givenNameCatarina Alexandra
person.givenNameLuísa
person.givenNameLuísa
person.identifierR-004-VNG
person.identifierNmxO5SIAAAAJ
person.identifier.ciencia-id2514-0E17-1D8D
person.identifier.ciencia-id4512-3435-689C
person.identifier.ciencia-id6D1A-17E5-1400
person.identifier.ciencia-id791B-C560-AEA2
person.identifier.orcid0000-0001-8732-710X
person.identifier.orcid0000-0002-1131-8773
person.identifier.orcid0000-0002-4077-855X
person.identifier.orcid0000-0003-4338-7703
person.identifier.ridM-6101-2013
person.identifier.scopus-author-id56031608100
person.identifier.scopus-author-id15831018900
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccess
rcaap.typearticle
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