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Autoantibodies against myelin oligodendrocyte glycoprotein in a subgroup of patients with psychotic symptoms

2025-07-18Artigo científico Acesso aberto
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datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg09:Indústria, Inovação e Infraestruturas
datacite.subject.sdg10:Reduzir as Desigualdades
dc.contributor.authorBurgt, Nikita A. van de
dc.contributor.authorKulsvehagen, Laila
dc.contributor.authorMané-Damas, Marina
dc.contributor.authorLutz, Luc
dc.contributor.authorLecourt, Anne-Catherine
dc.contributor.authorMonserrat, Clara
dc.contributor.authorVinke, Anita M.
dc.contributor.authorKüçükali, Cem İ.
dc.contributor.authorZong, Shenghua
dc.contributor.authorHoffmann, Carolin
dc.contributor.authorGonzález-Vioque, Emiliano
dc.contributor.authorArango, Celso
dc.contributor.authorLeibold, Nicole K.
dc.contributor.authorLosen, Mario
dc.contributor.authorMolenaar, Peter C.
dc.contributor.authorTüzün, Erdem
dc.contributor.authorBeveren, Nico J. M. van
dc.contributor.authorMané, Anna
dc.contributor.authorRouhl, Rob P. W.
dc.contributor.authorAmelsvoort, Therese A. M. J. van
dc.contributor.authorPröbstel, Anne-Katrin
dc.contributor.authorMartinez-Martinez, Pilar
dc.date.accessioned2026-05-13T08:40:17Z
dc.date.available2026-05-13T08:40:17Z
dc.date.issued2025-07-18
dc.description.abstractThe presence of autoantibodies against myelin oligodendrocyte glycoprotein (MOG) is a hallmark of MOG antibody-associated disease (MOGAD), a recently defined demyelinating disease entity presenting with core clinical features of optic neuritis, myelitis, and acute disseminated encephalomyelitis. Although MOG antibodies have also been described in a small number of patients with other conditions, including mental disorders, their prevalence and clinical specificity in patients with isolated psychotic symptoms remain unclear. Here, we screened sera from 262 patients with at least one psychotic episode and 166 control subjects for the presence of MOG antibodies of the immunoglobulin G (IgG) isotype with a live cell-based assay. Serum reactivity to additional antigens was assessed by immunohistochemistry. Four patients, representing 1.5% of the patient cohort, and one control individual, representing. 0.6% of the healthy control cohort, were seropositive for MOG-IgG antibodies. Of the four MOG-IgG seropositive patients, three experienced visual hallucinations. Overall, MOG antibodies were detected at a low frequency in patients with psychotic episodes. While we cannot exclude the possibility of false-positive results or seroconversion due to secondary myelin damage, the association with visual hallucinations in three out of four MOG-IgG seropositive patients may point toward an underlying autoimmune etiology.eng
dc.description.sponsorship97794-27-9; 308067-58-5; 50-24-8; 194609; 211318
dc.identifier.doi10.3389/fneur.2025.1593042
dc.identifier.issn1664-2295
dc.identifier.urihttp://hdl.handle.net/10400.1/28937
dc.language.isoeng
dc.peerreviewedyes
dc.publisherFrontiers Media SA
dc.relationMolecular, Structural and Cellular Microbiology – Instituto de Tecnologia Química e Biológica António Xavier
dc.relation.ispartofFrontiers in Neurology
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectMyelin oligodendrocyte glycoprotein antibody-associated disease
dc.subjectAutoantibodies
dc.subjectNeuroinflammation
dc.subjectPsychiatry
dc.subjectMental disorders
dc.subjectPsychosis
dc.titleAutoantibodies against myelin oligodendrocyte glycoprotein in a subgroup of patients with psychotic symptomseng
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberUIDP/04612/2020
oaire.awardTitleMolecular, Structural and Cellular Microbiology – Instituto de Tecnologia Química e Biológica António Xavier
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04612%2F2020/PT
oaire.citation.startPage1593042
oaire.citation.titleFrontiers in Neurology
oaire.citation.volume16
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameHoffmann
person.givenNameCarolin
person.identifier.ciencia-id211F-792C-1B73
person.identifier.orcid0000-0002-2528-7541
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
relation.isAuthorOfPublication50a4d3cc-b575-4d58-8df8-a51bed2914bb
relation.isAuthorOfPublication.latestForDiscovery50a4d3cc-b575-4d58-8df8-a51bed2914bb
relation.isProjectOfPublicationed9ddd48-d587-4c1c-ad47-449e5d8c782e
relation.isProjectOfPublication.latestForDiscoveryed9ddd48-d587-4c1c-ad47-449e5d8c782e

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