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The osteogenic and mineralogenic potential of the microalgae Skeletonema costatum and Tetraselmis striata CTP4 in fish models

2023-10Journal article Open Access
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dc.contributor.authorCarletti, Alessio
dc.contributor.authorRosa, Joana
dc.contributor.authorPes, Katia
dc.contributor.authorBorges, Inês
dc.contributor.authorSantos, Tamara
dc.contributor.authorBarreira, Luísa
dc.contributor.authorVarela, João
dc.contributor.authorPereira, Hugo
dc.contributor.authorCancela, M. Leonor
dc.contributor.authorJ. Gavaia, Paulo
dc.contributor.authorLaizé, Vincent
dc.date.accessioned2023-12-13T11:31:11Z
dc.date.available2023-12-13T11:31:11Z
dc.date.issued2023-10
dc.description.abstractSkeletal disorders are problematic aspects for the aquaculture industry as skeletal deformities, which affect most species of farmed fish, increase production costs and affect fish welfare. Following recent findings that show the presence of osteoactive compounds in marine organisms, we evaluated the osteogenic and mineralogenic potential of commercially available microalgae strains Skeletonema costatum and Tetraselmis striata CTP4 in several fish systems. Ethanolic extracts increased extracellular matrix mineralization in gilthead seabream (Sparus aurata) bone-derived cell cultures and promoted osteoblastic differentiation in zebrafish (Danio rerio) larvae. Long-term dietary exposure to both extracts increased bone mineralization in zebrafish and upregulated the expression of genes involved in bone formation (sp7, col1a1a, oc1, and oc2), bone remodeling (acp5a), and antioxidant defenses (cat, sod1). Extracts also improved the skeletal status of zebrafish juveniles by reducing the incidence of skeletal anomalies. Our results indicate that both strains of microalgae contain osteogenic and mineralogenic compounds, and that ethanolic extracts have the potential for an application in the aquaculture sector as dietary supplements to support fish bone health. Future studies should also identify osteoactive compounds and establish whether they can be used in human health to broaden the therapeutic options for bone erosive disorders such as osteoporosis.pt_PT
dc.description.sponsorshipEuropean Maritime and Fisheries Fund (EMFF/FEAMP) through the National Operational Programme MAR2020 16-02-01-FMP-0057/OSTEOMAR, European Union (EU) Marie Curie Actions EAPA/151/2016/BLUEHUMAN, operational programmes CRESC Algarve 2020 and COMPETE 2020 through project EMBRC ALG-01-0145-FEDER-022121pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1007/s00018-023-04953-ypt_PT
dc.identifier.eissn1420-9071
dc.identifier.urihttp://hdl.handle.net/10400.1/20221
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.relationAquaculture meets Biomedicine: Innovation in Skeletal Health research.
dc.relationAlgarve Centre for Marine Sciences
dc.relationAlgarve Centre for Marine Sciences
dc.relationCentre for Marine and Environmental Research
dc.relationEffects of marine derived extracts on osteogenesis and mineralogenesis
dc.relationMicrobiome-mediated improvement of industrial Chlorella biomass production
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectMarine microalgaept_PT
dc.subjectOsteoanabolic activitypt_PT
dc.subjectMineralogenic cell linept_PT
dc.subjectSkeletal deformitiespt_PT
dc.titleThe osteogenic and mineralogenic potential of the microalgae Skeletonema costatum and Tetraselmis striata CTP4 in fish modelspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAquaculture meets Biomedicine: Innovation in Skeletal Health research.
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleCentre for Marine and Environmental Research
oaire.awardTitleEffects of marine derived extracts on osteogenesis and mineralogenesis
oaire.awardTitleMicrobiome-mediated improvement of industrial Chlorella biomass production
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/766347/EU
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04326%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04326%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0101%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/2021.05406.BD/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F140143%2F2018/PT
oaire.citation.issue10pt_PT
oaire.citation.titleCellular and Molecular Life Sciencespt_PT
oaire.citation.volume80pt_PT
oaire.fundingStreamH2020
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamOE
person.familyNameCarletti
person.familyNameRosa
person.familyNameSantos
person.familyNameBarreira
person.familyNameVarela
person.familyNameCancela
person.familyNameGavaia
person.familyNameLaizé
person.givenNameAlessio
person.givenNameJoana
person.givenNameTamara
person.givenNameLuísa
person.givenNameJoão
person.givenNameM. Leonor
person.givenNamePaulo
person.givenNameVincent
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person.identifier.orcid0000-0001-9008-4436
person.identifier.orcid0000-0002-4077-855X
person.identifier.orcid0000-0003-3101-693X
person.identifier.orcid0000-0003-3114-6662
person.identifier.orcid0000-0002-9582-1957
person.identifier.orcid0000-0001-9565-9198
person.identifier.ridM-4223-2013
person.identifier.ridA-6470-2011
person.identifier.ridB-4463-2008
person.identifier.scopus-author-id36505067900
person.identifier.scopus-author-id55741416000
person.identifier.scopus-author-id6507104377
person.identifier.scopus-author-id6602982778
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameEuropean Commission
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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