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Effects of body weight regain on leptin levels: a systematic review and meta-analysis

2021Journal article Restricted access
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dc.contributor.authorRostami Rayeni, Najme
dc.contributor.authorAbdollahzad, Hadi
dc.contributor.authorAlibakhshi, Pooya
dc.contributor.authorMorvaridzadeh, Mojgan
dc.contributor.authorHeydari, Hafez
dc.contributor.authorDehnad, Afsaneh
dc.contributor.authorKhorshidi, Masoud
dc.contributor.authorIzadi, Azimeh
dc.contributor.authorShidfar, Farzad
dc.contributor.authorEstêvão, Dulce
dc.contributor.authorOmidi, Amirhosein
dc.contributor.authorHeshmati, Javad
dc.date.accessioned2022-02-14T12:34:32Z
dc.date.available2022-02-14T12:34:32Z
dc.date.issued2021
dc.description.abstractBackground: There are different changes observed before and after diet therapy, and also after weight regain. However, there is not sufficient information regarding weight regain and hormonal changes. Purpose: The purpose of this study was to review the connection between weight regain and leptin concentration levels. Methods: MEDLINE, SCOPUS, Web of Science, and the Cochrane Library were searched for interventional articles published from January 1, 1980, to June 30, 2020. Randomized clinical trials with parallel or cross over design assessing leptin concentrations at the baseline and at the end of study were reviewed. Two independent reviewers extracted data related to study design, year of publication, country, age, gender, body mass index (BMI), duration of the following up period and mean +/- SD of other intended variables. Results: Four articles were included, published between 2004 and 2016. Three of them were conducted in the US and one of them in Netherland. Sample size of the studies ranged between 25 and 148 participants. The range of following up period was from13 to 48 weeks. The age range of participants was from 34 to 44 years. Our analysis shows that weight regain could reduce leptin levels, but this change is not statistically significant. Conclusion: This review suggests that weight regain may induce a non-significant reduction in leptin level. However, the limited number and great heterogeneity between the included studies may affect the presented results and there are still need to well-designed, large population studies to determine the relationship between weight regain and leptin levels.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.cyto.2021.155647pt_PT
dc.identifier.issn1043-4666
dc.identifier.urihttp://hdl.handle.net/10400.1/17546
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.subjectWeight regainpt_PT
dc.subjectLeptinpt_PT
dc.subjectBMIpt_PT
dc.subjectSystematic reviewpt_PT
dc.titleEffects of body weight regain on leptin levels: a systematic review and meta-analysispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage155647pt_PT
oaire.citation.titleCytokinept_PT
oaire.citation.volume148pt_PT
person.familyNameEstêvão
person.givenNameMaria Dulce da Mota Antunes de Oliveira
person.identifierI-4695-2014
person.identifier.ciencia-id881B-53E8-0DB1
person.identifier.orcid0000-0002-7151-8363
person.identifier.scopus-author-id8381590400
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication67887883-2695-48cc-8221-aa46780ac143
relation.isAuthorOfPublication.latestForDiscovery67887883-2695-48cc-8221-aa46780ac143

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