Screening polyoxometalates as aquaporin inhibitors for cancer therapeutics

Pimpao, C.; Coxixo, A. S.; Aureliano, M.; Rompel, A.; Soveral, G.

http://hdl.handle.net/10400.1/12829

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Aquaporins (AQPs) are transmembrane protein channels that facilitate the diffusion of water and glycerol across cell membranes, crucial for water and energy homeostasis. These proteins were found overexpressed in different cancer cells and tissues, being involved in cell proliferation and migration, tumor formation, and angiogenesis, suggesting their great potential as novel drug targets for cancer treatment. Identification of potent and selective aquaporin inhibitors to be used in cancer therapeutics is of utmost importance. Polyoxometalates (POMs) are transition metal complexes that exhibit a broad diversity of structures and properties.