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Magnetite nanoparticles functionalized with propolis against methicillin resistant strains of Staphylococcus aureus

2019Journal article Restricted access
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dc.contributor.authorEL-GEUNDOUZ, Soukaina
dc.contributor.authorLyoussi, Badiaa
dc.contributor.authorLourenço, João P.
dc.contributor.authorRosa Da Costa, Ana
dc.contributor.authorMiguel, Maria
dc.contributor.authorBarrocas Dias, Cristina
dc.contributor.authorManhita, Ana
dc.contributor.authorJordao, Luisa
dc.contributor.authorNogueira, Isabel
dc.contributor.authorFaleiro, Maria Leonor
dc.date.accessioned2019-11-12T16:38:01Z
dc.date.available2019-11-12T16:38:01Z
dc.date.issued2019
dc.description.abstractMagnetite nanoparticles (MNPs) have been evaluated for inhibiting microbial growth and biofilm formation. In this study the effect of the nanocomposite Moroccan propolis extract / MNPs acting against methicillin resistant strains of Staphylococcus aureus (MRSA) was evaluated. Chemical composition of propolis was established by pyrolysis coupled to gas chromatography and mass spectrometry method (pyrolysis GC/MS). MNPs were obtained through the co-precipitation method. The fabricated nanostructure was characterized by X-ray Diffraction (DRX), Transmission Electron Microscopy (TEM), and Fourier Transform-Infrared Spectroscopy (FTIR). TEM of MNPs provided a particle average size of 15 nm, FTIR spectral analysis enabled a fast way of identification of MNPs, attesting the occurrence of the different combinations. The use of MNPs loaded with propolis and the antibiotic chloramphenicol at Minimum Inhibitory Concentration (MIC) value inhibited the bacterial growth of MSSA (methicillin susceptible strain of S. aureus) and MRSA strains. After the treatment with MNPs-OA-P-CLo nanocomposite (MNPs with oleic acid, propolis and chloramphenicol), the disruption of the bacterial cell was observed by TEM. The combination of propolis and chloramphenicol in free form at MIC value largely impaired both MSSA and MRSA strains as, after 2 h of treatment, no viable cells of MRSA 2 and MRSA 16 were recovered. Hence, the results elucidated a new antibacterial nanocomposite synthesis, for possible applications as prospective nanoantibacterial agents or drug carriers.pt_PT
dc.description.sponsorshipUID/QUI/04023/2016
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doihttps://doi.org/10.1016/j.jtice.2019.05.018
dc.identifier.issn1876-1070
dc.identifier.urihttp://hdl.handle.net/10400.1/12878
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationCenter for Mediterranean Bioresources and food
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S1876107019302391pt_PT
dc.subjectPyrolysis GC/MSpt_PT
dc.subjectFlavonoidspt_PT
dc.subjectNanotechnologypt_PT
dc.subjectAntibacterial activitypt_PT
dc.subjectPropolis extract / magnetite nanoparticlespt_PT
dc.titleMagnetite nanoparticles functionalized with propolis against methicillin resistant strains of Staphylococcus aureuspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCenter for Mediterranean Bioresources and food
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04449%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FBIA%2F04325%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FBIM%2F04773%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FQUI%2F00100%2F2013/PT
oaire.citation.endPage33pt_PT
oaire.citation.startPage25pt_PT
oaire.citation.titleJournal of the Taiwan Institute of Chemical Engineerspt_PT
oaire.citation.volume102pt_PT
oaire.fundingStream5876
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream5876
oaire.fundingStream5876
person.familyNameEl-Guendouz
person.familyNameLourenço
person.familyNameRosa da Costa
person.familyNameMiguel
person.familyNameFaleiro
person.givenNameSoukaina
person.givenNameJoão P.
person.givenNameAna M
person.givenNameMaria da Graça
person.givenNameMaria Leonor
person.identifierhttps://scholar.google.com/citations?user=CYBI8q8AAAAJ&hl=fr
person.identifier634248
person.identifier305029
person.identifier252666
person.identifier.ciencia-id3E11-53A1-4D90
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person.identifier.ciencia-idA418-A85E-5DB1
person.identifier.ciencia-id6110-6FE7-DF28
person.identifier.ciencia-id281D-5E01-F09A
person.identifier.orcid0000-0002-3341-9452
person.identifier.orcid0000-0002-0501-6672
person.identifier.orcid0000-0003-0225-9537
person.identifier.orcid0000-0003-2507-4228
person.identifier.orcid0000-0002-3878-6948
person.identifier.ridA-7758-2008
person.identifier.ridE-2165-2012
person.identifier.scopus-author-id57190122389
person.identifier.scopus-author-id57195730600
person.identifier.scopus-author-id53986075100
person.identifier.scopus-author-id35562054500
person.identifier.scopus-author-id6507927018
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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