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Protective effects of Lavandula viridis L'Hér extracts and rosmarinic acid against H2O2-induced oxidative damage in A172 human astrocyte cell line

2013Journal article Restricted access
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dc.contributor.authorCosta, Patrícia
dc.contributor.authorSarmento, Bruno
dc.contributor.authorGonçalves, Sandra
dc.contributor.authorRomano, Anabela
dc.date.accessioned2015-06-18T10:12:40Z
dc.date.available2015-06-18T10:12:40Z
dc.date.issued2013
dc.description.abstractWe investigated the neuroprotective effect of Lavandula viridis extracts (infusion, water:ethanol and methanol) and rosmarinic acid, the major compound present in the extracts, against oxidative damage induced by hydrogen peroxide (H2O2) in A172 human astrocyte cell line regarding the neurotoxic effect, intracellular reactive oxygen species (ROS) production and the activity of the antioxidant enzyme catalase (CAT). We found that L. viridis extracts and rosmarinic acid protected A172 astrocytes against H2O2 and reduced intracellular ROS accumulation. Furthermore, the protection effect was not caused by modulation of CAT suggesting that other intracellular mechanisms are involved in the neuroprotective effect. Our results highlight that L. viridis extracts and rosmarinic acid have beneficial effects against oxidative damage associated with neurodegenerative diseases. © 2013.
dc.identifier.doihttps://dx.doi.org/10.1016/j.indcrop.2013.07.054
dc.identifier.issn0926-6690
dc.identifier.otherAUT: ARO01015;
dc.identifier.urihttp://hdl.handle.net/10400.1/6451
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relation.isbasedonP-008-DAH
dc.subjectLavandula viridis
dc.subjectRosmarinic acid
dc.subjectNeuroprotective effect
dc.subjectPhenolic compounds
dc.subjectReactive oxygen species
dc.subjectHydrogen peroxide
dc.titleProtective effects of Lavandula viridis L'Hér extracts and rosmarinic acid against H2O2-induced oxidative damage in A172 human astrocyte cell line
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage365
oaire.citation.startPage361
oaire.citation.titleIndustrial Crops and Products
oaire.citation.volume50
person.familyNameGonçalves
person.familyNameRomano
person.givenNameSandra
person.givenNameAnabela
person.identifier.ciencia-id9F19-E3AE-2C59
person.identifier.ciencia-id8A18-7E9A-3B0E
person.identifier.orcid0000-0002-3038-4434
person.identifier.orcid0000-0002-7204-7428
person.identifier.ridM-6988-2017
person.identifier.scopus-author-id8583003200
person.identifier.scopus-author-id56249997600
rcaap.rightsrestrictedAccess
rcaap.typearticle
relation.isAuthorOfPublicationa8b335b2-45cc-4578-89b0-153273014280
relation.isAuthorOfPublicatione3343b60-17d3-4f5e-a2bf-06f26da69206
relation.isAuthorOfPublication.latestForDiscoverya8b335b2-45cc-4578-89b0-153273014280

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