In vitro biological activity screening of arbutus unedo leaves in light of their traditional use

Nunes, Ricardo; Saraiva De Carvalho, Isabel; Paśko, Paweł; Tyszka – Czochara, Małgorzata; Szewczyk, Agnieszka; Szlósarczyk, Marek; Podolak, Irma; Galanty, Agnieszka

http://hdl.handle.net/10400.1/20128

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Autores

Nunes, Ricardo

Saraiva De Carvalho, Isabel

Paśko, Paweł

Tyszka – Czochara, Małgorzata

Resumo(s)

The biological activity of A. unedo leaves, in relation to their traditional medicinal use in treating gastrointestinal and urinary tract diseases was verified. The ethanol extract of the leaves was quantitatively described in terms of flavonoids and phenolic acids (RP-HPLC), and zinc (voltametric analysis) and subjected to cytotoxic (MTT), antioxidant (TPC, TFC, TAA, RP, DPPH, and FRAP), antibacterial (disc diffusion), and antidiabetic assays (enzyme inhibition) in vitro. The extract was highly cytotoxic against prostate cancer cells, with less impact on colon carcinomas, while being nontoxic to normal prostate and kidney cells, and demonstrated antioxidant and antidiabetic activities.

Palavras-chave

Antioxidant Antidiabetic Antibacterial Cytotoxic

URI

http://hdl.handle.net/10400.1/20128

Projetos de investigação

MICROMEDRONHO - DESIGNER DE MICROCÁPSULAS DE ARBUTUS UNEDO FOLHAS, FRUTOS E FLORES POR SPRAY DRYING PARA SUPLEMENTOS E ALIMENTOS FUNCIONAIS

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Editora

Taylor & Francis

DOI

10.1080/10496475.2023.2254284

Coleções

FCT2-Artigos (em revistas ou actas indexadas)

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