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Current (Food) allergenic risk assessment: is it fit for novel foods? status quo and identification of gaps

2018-01Journal article Open access
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dc.contributor.authorMazzucchelli, Gabriel
dc.contributor.authorHolzhauser, Thomas
dc.contributor.authorCirkovic Velickovic, Tanja
dc.contributor.authorDiaz Perales, Araceli
dc.contributor.authorMolina, Elena
dc.contributor.authorRoncada, P.
dc.contributor.authorRodrigues, Pedro
dc.contributor.authorVerhoeckx, Kitty
dc.contributor.authorHoffmann-Sommergruber, Karin
dc.date.accessioned2018-12-07T14:53:04Z
dc.date.available2018-12-07T14:53:04Z
dc.date.issued2018-01
dc.description.abstractFood allergies are recognized as a global health concern. In order to protect allergic consumers from severe symptoms, allergenic risk assessment for well-known foods and foods containing genetically modified ingredients is installed. However, population is steadily growing and there is a rising need to provide adequate protein-based foods, including novel sources, not yet used for human consumption. In this context safety issues such as a potential increased allergenic risk need to be assessed before marketing novel food sources. Therefore, the established allergenic risk assessment for genetically modified organisms needs to be re-evaluated for its applicability for risk assessment of novel food proteins. Two different scenarios of allergic sensitization have to be assessed. The first scenario is the presence of already known allergenic structures in novel foods. For this, a comparative assessment can be performed and the range of cross-reactivity can be explored, while in the second scenario allergic reactions are observed toward so far novel allergenic structures and no reference material is available. This review summarizes the current analytical methods for allergenic risk assessment, highlighting the strengths and limitations of each method and discussing the gaps in this assessment that need to be addressed in the near future.
dc.description.sponsorshipAustrian Science Fund [FWF SFB F4603]; Ministry of Education, Science and Technological Development of the Republic of Serbia [OI172024]; MINECO, Spain [AGL2014-59771-R]; PROMAR: Projetos Pilotos e a Transformacao de Embarcacoes de Pesca [31-03-05-FEP-0060]
dc.description.sponsorshipMolecular properties and modifications of some respiratory and nutritional allergens (MESTD /Basic Research (BR or ON); MINECO, Spain [AGL2014-59771-R]; PROMAR: Projetos Pilotos e a Transformacao de Embarcacoes de Pesca [31-03-05-FEP-0060]; Austrian Science Fund [FWF SFB F4603]
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1002/mnfr.201700278
dc.identifier.issn1613-4125
dc.identifier.issn1613-4133
dc.identifier.urihttp://hdl.handle.net/10400.1/11340
dc.language.isoeng
dc.peerreviewedyes
dc.publisherWiley
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectSimulated gastric fluid
dc.subjectX-ray crystallography
dc.subjectMajor peanut allergen
dc.subjectBla G 1
dc.subjectMass-spectrometry
dc.subjectStructural basis
dc.subjectIn-Vitro
dc.subjectCrystal-structure
dc.subject2S Albumin
dc.subjectGastrointestinal digestion
dc.titleCurrent (Food) allergenic risk assessment: is it fit for novel foods? status quo and identification of gaps
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue1
oaire.citation.startPage1700278
oaire.citation.titleMolecular Nutrition and Food Research
oaire.citation.volume62
person.familyNameMazzucchelli
person.familyNameDiaz Perales
person.familyNameRoncada
person.familyNameRodrigues
person.familyNameHoffmann-Sommergruber
person.givenNameGabriel
person.givenNameAraceli
person.givenNamePaola
person.givenNamePedro
person.givenNameKarin
person.identifier64075
person.identifier.orcid0000-0002-8757-8133
person.identifier.orcid0000-0002-1093-3627
person.identifier.orcid0000-0002-0114-5872
person.identifier.orcid0000-0002-9668-1204
person.identifier.orcid0000-0002-8830-058X
person.identifier.ridD-8433-2016
person.identifier.ridC-5263-2013
person.identifier.ridM-3406-2013
person.identifier.scopus-author-id6602872247
person.identifier.scopus-author-id55574122415
person.identifier.scopus-author-id55107531000
rcaap.rightsopenAccess
rcaap.typearticle
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relation.isAuthorOfPublication.latestForDiscovery905362a9-78d8-4bcd-89de-b0406ebfdb17

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