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New insights into the chemical profiling, cytotoxicity and bioactivity of four Bunion species

2019-09Journal article Restricted
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dc.contributor.authorZengin, Gokhan
dc.contributor.authorPaksoy, Mehmet Yavuz
dc.contributor.authorAumeeruddy, Muhammad Zakariyyah
dc.contributor.authorGlamocilja, Jasmina
dc.contributor.authorSokovic, Marina
dc.contributor.authorDiuzheva, Alina
dc.contributor.authorJeko, Jozsef
dc.contributor.authorCziaky, Zoltan
dc.contributor.authorRodrigues, Maria Joao
dc.contributor.authorCustodio, Luisa
dc.contributor.authorMahomoodally, Mohamad Fawzi
dc.date.accessioned2020-07-24T10:51:45Z
dc.date.available2020-07-24T10:51:45Z
dc.date.issued2019-09
dc.description.abstractBunium species have been reported to be used both as food and in traditional medicines. The scientific community has attempted to probe into the pharmacological and chemical profiles of this genus. Nonetheless, many species have not been investigated fully to date. In this study, we determined the phenolic components, antimicrobial, antioxidant, and enzyme inhibitory activities of aerial parts of four Bunium species (B. sayai, B. pinnatifolium, B. brachyactis and B. macrocatpum). Results showed that B. microcarpum and B. pinnatifolium were strong antioxidants as evidenced in the DPPH, ABTS, CUPRAC, and FRAP assays. B. brachyactis was the most effective metal chelator, and displayed high enzyme inhibition against cholinesterase, tyrosinase, amylase, glucosidase, and lipase. The four species showed varied antimicrobial activity against each microorganism. Overall, they showed high activity against P. mirabilis and E. call (MIC and MBC < 1 mg(-1)). B. brachyactis was more effective against Aspergillus versicolor compared to the standard drug ketoconazole. B. brachyactis was also more effective than both ketoconazole and bifonazole against Trichoderma viride. B. sayai was more effective than ketoconazole in inhibiting A. fumigates. B. sayai was most non-toxic to HEK 293 (cellular viability = 117%) and HepG2 (cellular viability = 104%). The highest level of TPC was observed in B. pinnatifolium (35.94 mg GAE g(-1)) while B. microcarpum possessed the highest TFC (39.21 mg RE g(-1)). Seventy four compounds were detected in B. microcarpum, 70 in B. brachyactis, 66 in B. sayai, and 51 in B. pinnatifolium. Quinic acid, chlorogenic acid, pantothenic acid, esculin, isoquercitrin, rutin, apigenin, and scopoletin were present in all the four species. This study showed that the four Bunium species are good sources of biologically active compounds with pharmaceutical and nutraceutical potential.
dc.identifier.doi10.1016/j.foodres.2019.05.013
dc.identifier.issn0963-9969
dc.identifier.issn1873-7145
dc.identifier.urihttp://hdl.handle.net/10400.1/14266
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.subjectEssential oil content
dc.subjectIn-vitro
dc.subjectAntibacterial activity
dc.subjectAntioxidant properties
dc.subjectMedicinal-plants
dc.subjectMechanism
dc.subjectConstituents
dc.subjectNaringenin
dc.subjectComponents
dc.subjectExtracts
dc.titleNew insights into the chemical profiling, cytotoxicity and bioactivity of four Bunion species
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage424
oaire.citation.startPage414
oaire.citation.titleFood Research International
oaire.citation.volume123
person.familyNameRodrigues
person.givenNameMaria João
person.identifierR-004-VNG
person.identifier.ciencia-id2514-0E17-1D8D
person.identifier.orcid0000-0001-8732-710X
person.identifier.scopus-author-id56031608100
rcaap.rightsrestrictedAccess
rcaap.typearticle
relation.isAuthorOfPublication12c32925-de9e-4289-bdd5-1d655d7a278c
relation.isAuthorOfPublication.latestForDiscovery12c32925-de9e-4289-bdd5-1d655d7a278c

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