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Feeding and the rhodopsin family g-protein coupled receptors in nematodes and arthropods

2012Journal article Open access
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dc.contributor.authorCardoso, João CR
dc.contributor.authorFélix, Rute C.
dc.contributor.authorFonseca, V. G.
dc.contributor.authorPower, Deborah
dc.date.accessioned2014-10-22T15:46:41Z
dc.date.available2014-10-22T15:46:41Z
dc.date.issued2012
dc.description.abstractIn vertebrates, receptors of the rhodopsin G-protein coupled superfamily (GPCRs) play an important role in the regulation of feeding and energy homeostasis and are activated by peptide hormones produced in the brain-gut axis.These peptides regulate appetite and energy expenditure by promoting or inhibiting food intake. Sequence and function homologs of human GPCRs involved in feeding exist in the nematode roundworm, Caenorhabditis elegans (C. elegans), and the arthropod fruit fly, Drosophila melanogaster (D. melanogaster), suggesting that the mechanisms that regulate food intake emerged early and have been conserved during metazoan radiation. Nematodes and arthropods are the most diverse and successful animal phyla on Earth. They can survive in a vast diversity of environments and have acquired distinct life styles and feeding strategies.The aim of the present review is to investigate if this diversity has affected the evolution of invertebrate GPCRs. Homologs of the C. elegans and D. melanogaster rhodopsin receptorswere characterized in the genome of other nematodes and arthropods and receptor evolution compared.With the exception of bombesin receptors (BBR) that are absent from nematodes, a similar gene complement was found. In arthropods, rhodopsin GPCR evolution is characterized by species-specific gene duplications and deletions and in nematodes by gene expansions in species with a free-living stage and gene deletions in representatives of obligate parasitic taxa. Based upon variation in GPCR gene number and potentially divergent functions within phyla we hypothesize that life style and feeding diversity practiced by nematodes and arthropods was one factor that contributed to rhodopsin GPCR gene evolution. Understanding how the regulation of food intake has evolved in invertebrates will contribute to the development of novel drugs to control nematodes and arthropods and the pests and diseases that use them as vectors.por
dc.description.sponsorshipFCT PTDC/BIA-BCM/114395/2009; SFRH/BPD/80447/2011.por
dc.identifier.citationCardoso JC, Félix RC, Fonseca VG, Power DM., "Feeding and the rhodopsin family g-protein coupled receptors in nematodes and arthropods" in Front Endocrinol (Lausanne). 2012 Dec 18;3:157.por
dc.identifier.doihttp://dx.doi.org/10.3389/fendo.2012.00157
dc.identifier.otherAUT: DPO00386;
dc.identifier.urihttp://hdl.handle.net/10400.1/5415
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherFrontierspor
dc.subjectRhodopsin GPCRpor
dc.subjectFeedingpor
dc.subjectConservationpor
dc.subjectEvolutionpor
dc.subjectInvertebratespor
dc.titleFeeding and the rhodopsin family g-protein coupled receptors in nematodes and arthropodspor
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBIA-BCM%2F114395%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F80447%2F2011/PT
oaire.citation.titleFrontiers in Endocrinologypor
oaire.citation.volume3por
oaire.fundingStream3599-PPCDT
oaire.fundingStreamSFRH
person.familyNameCardoso
person.familyNamePower
person.givenNameJoão
person.givenNameDeborah Mary
person.identifier14332
person.identifier.ciencia-id8B16-F203-2AFC
person.identifier.ciencia-id891A-8A44-3CAE
person.identifier.orcid0000-0001-7890-0170
person.identifier.orcid0000-0003-1366-0246
person.identifier.ridM-4151-2013
person.identifier.scopus-author-id7201822956
person.identifier.scopus-author-id7101806760
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspor
rcaap.typearticlepor
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