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Vanadate and bone metabolism: effect on proliferation and mineralization of fish bone-derived cells

2007Conference object Open access
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dc.contributor.authorTiago, Daniel
dc.contributor.authorLaizé, Vincent
dc.contributor.authorCancela, Leonor
dc.contributor.authorAureliano, M.
dc.date.accessioned2012-06-26T10:54:31Z
dc.date.available2012-06-26T10:54:31Z
dc.date.issued2007
dc.description.abstractVanadate is known for mimicking insulin action through activation of insulin and/or insulin like growth factor 1 (IGF 1) receptors. Vanadate insulin- like effect on bone-related metabolism has been previously investigated using mammalian in vitro cell systems but other vertebrate systems have rarely been used. We have recently demonstrated the suitability of a fish bone derived cell line (VSa13) to study anti-mineralogenic effects of vanadate. Here, we propose that vanadate stimulation of cell proliferation involves MAPK signalling pathway and IGF 1 receptor activation, while impairment of extracellular matrix (ECM) mineralization is likely to involve both MAPK and PI 3K pathways and insulin receptor activation.por
dc.identifier.urihttp://hdl.handle.net/10400.1/1308
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherMedimondpor
dc.subjectVanadatepor
dc.subjectBonepor
dc.titleVanadate and bone metabolism: effect on proliferation and mineralization of fish bone-derived cellspor
dc.typeconference object
dspace.entity.typePublication
oaire.citation.endPage186por
oaire.citation.startPage183por
oaire.citation.titleEuropean Meeting of the Society for Free Radical Research International,Free Radicals, Health and Lifestylepor
person.familyNameTiago
person.familyNameLaizé
person.familyNameCancela
person.familyNameAureliano
person.givenNameDaniel
person.givenNameVincent
person.givenNameM. Leonor
person.givenNameManuel
person.identifier584146
person.identifier.ciencia-idAA14-3490-DC5E
person.identifier.orcid0000-0001-8418-6292
person.identifier.orcid0000-0001-9565-9198
person.identifier.orcid0000-0003-3114-6662
person.identifier.orcid0000-0003-4858-3201
person.identifier.ridB-4463-2008
person.identifier.ridI-3283-2012
person.identifier.scopus-author-id14422711000
person.identifier.scopus-author-id6602982778
person.identifier.scopus-author-id6603412860
rcaap.rightsopenAccesspor
rcaap.typeconferenceObjectpor
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relation.isAuthorOfPublication.latestForDiscoveryb9bbfe32-3dfe-4131-ad14-a4394008447f

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