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Are Physicochemical Properties Shaping the Allergenic Potency of Animal Allergens?

2022-02Journal article Restricted access
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dc.contributor.authorCosta, Joana
dc.contributor.authorVilla, Caterina
dc.contributor.authorVerhoeckx, Kitty
dc.contributor.authorCirkovic-Velickovic, Tanja
dc.contributor.authorSchrama, Denise
dc.contributor.authorRoncada, Paola
dc.contributor.authorRodrigues, Pedro M.
dc.contributor.authorPiras, Cristian
dc.contributor.authorMartin-Pedraza, Laura
dc.contributor.authorMonaci, Linda
dc.contributor.authorMolina, Elena
dc.contributor.authorMazzucchelli, Gabriel
dc.contributor.authorMafra, Isabel
dc.contributor.authorLupi, Roberta
dc.contributor.authorLozano-Ojalvo, Daniel
dc.contributor.authorLarre, Colette
dc.contributor.authorKlueber, Julia
dc.contributor.authorGelencser, Eva
dc.contributor.authorBueno-Diaz, Cristina
dc.contributor.authorDiaz-Perales, Araceli
dc.contributor.authorBenede, Sara
dc.contributor.authorBavaro, Simona Lucia
dc.contributor.authorKuehn, Annette
dc.contributor.authorHoffmann-Sommergruber, Karim
dc.contributor.authorHolzhauser, Thomas
dc.date.accessioned2021-09-08T10:58:12Z
dc.date.available2021-09-08T10:58:12Z
dc.date.issued2022-02
dc.description.abstractKey determinants for the development of an allergic response to an otherwise 'harmless' food protein involve different factors like the predisposition of the individual, the timing, the dose, the route of exposure, the intrinsic properties of the allergen, the food matrix (e.g. lipids) and the allergen modification by food processing. Various physicochemical parameters can have an impact on the allergenicity of animal proteins. Following our previous review on how physicochemical parameters shape plant protein allergenicity, the same analysis was proceeded here for animal allergens. We found that each parameter can have variable effects, ranging on an axis from allergenicity enhancement to resolution, depending on its nature and the allergen. While glycosylation and phosphorylation are common, both are not universal traits of animal allergens. High molecular structures can favour allergenicity, but structural loss and uncovering hidden epitopes can also have a similar impact. We discovered that there are important knowledge gaps in regard to physicochemical parameters shaping protein allergenicity both from animal and plant origin, mainly because the comparability of the data is poor. Future biomolecular studies of exhaustive, standardised design together with strong validation part in the clinical context, together with data integration model systems will be needed to unravel causal relationships between physicochemical properties and the basis of protein allergenicity.
dc.description.sponsorshipCOST Office; COST (European Cooperation in Science and Technology)European Cooperation in Science and Technology (COST) [FA1402]; Fundacao para a Ciencia e TecnologiaPortuguese Foundation for Science and TechnologyEuropean Commission [UIDB 50006/2020]; POPH-QREN (FSE) [PD/BD/114576/2016]; FCTPortuguese Foundation for Science and TechnologyEuropean Commission [SFRH/BPD/102404/2014, UIDB/04326/2020]; Ministry of Education, Science and Technological Development of the Republic of Serbia [OI172024]; PRIDE program [PRIDE/11012546/NEXTIMMUNE]; FNR (Fonds National de la Recherche)Luxembourg National Research Fund; PMC (Personalised Medicine Consortium); ALLYFISH [Mar2020 16-02-01-FMP0014]; POPH-QREN (MCTES) [PD/BD/114576/2016]; [AlleRiskAssessPTDC/BAA-AGR/31720/2017]
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1007/s12016-020-08826-1
dc.identifier.issn1080-0549
dc.identifier.urihttp://hdl.handle.net/10400.1/17060
dc.language.isoeng
dc.peerreviewedyes
dc.publisherHUMANA PRESS INC
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationFood allergens: detection and structural properties as affected by processing and in vitro digestibility
dc.subjectAnimal allergens
dc.subjectProtein families
dc.subjectAllergenicity
dc.subjectFood processing
dc.subjectAllergen integrity
dc.subject.otherAllergy; Immunology
dc.titleAre Physicochemical Properties Shaping the Allergenic Potency of Animal Allergens?
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleFood allergens: detection and structural properties as affected by processing and in vitro digestibility
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_NORTE/PD%2FBD%2F114576%2F2016/PT
oaire.citation.titleClinical Reviews in Allergy & Immunology
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamPOR_NORTE
person.familyNameSchrama
person.familyNameRodrigues
person.givenNameDenise
person.givenNamePedro
person.identifier159154
person.identifier.ciencia-id501C-AC69-68C0
person.identifier.orcid0000-0003-0274-5957
person.identifier.orcid0000-0002-9668-1204
person.identifier.ridH-6511-2016
person.identifier.ridM-3406-2013
person.identifier.scopus-author-id55755583400
person.identifier.scopus-author-id55107531000
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccess
rcaap.typearticle
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