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Juncaceae species as sources of innovative bioactive compounds for the food industry: In vitro antioxidant activity, neuroprotective properties and in silico studies

2017-09Journal article Restricted
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dc.contributor.authorRodrigues, Maria João
dc.contributor.authorGangadhar N. Katkam, Dr.
dc.contributor.authorZengin, Gokhan
dc.contributor.authorMollica, Adriano
dc.contributor.authorVarela, João
dc.contributor.authorBarreira, Luísa
dc.contributor.authorL, Custódio
dc.date.accessioned2019-11-20T15:07:23Z
dc.date.available2019-11-20T15:07:23Z
dc.date.issued2017-09
dc.description.abstractSeveral Juncus species are traditionally used as sedative and to treat health problems like insomnia. This work was based on the hypothesis that Juncus acutus, J. maritimus and J. inflexus may have molecules with bioactivities relevant for the improvement of cognitive functions and thus with potential use as food additives and/or nutraceuticals. Therefore leaves and roots extracts of those species were evaluated for radical scavenging (RSA) and metal chelating activities, and for in vitro inhibition of acetyl-(AChE) and butyrylcholinesterase (BuChE). The bioactive compound was isolated and identified by HPLC-DAD, and its anticholinesterase capacity was determined by different assays. Docking studies were performed to elucidate its inhibitory mechanism. The dichloromethane root extract of J. acutus had the highest RSA against DPPH and ABTS radicals, and the dichloromethane extract of J. maritimus leaves had the uppermost FRAP. The dichloromethane extract from J. acutus leaves had the strongest BuChE inhibition. Juncunol was the bioactive compound, exhibiting dual anticholinesterase capacity on enzyme-based assays and AChE inhibition in neuronal and glial cells in vitro. Molecular docking studies indicate juncunol as a competitive reversible inhibitor. Our results suggest that Juncus spp. can be sources of bioactive compounds with application in the food industry as cognitive-enhancer nutraceuticals. (C) 2017 Elsevier Ltd. All rights reserved.
dc.description.sponsorshipFCT - Foundation for Science and Technology [PTDC/MAR-EST/4346/2012, CCMAR/Multi/04326/2013]
dc.description.sponsorshipPortuguese National Budget
dc.description.sponsorshipFCT [IF/00049/2012]
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1016/j.fct.2017.04.006
dc.identifier.issn0278-6915
dc.identifier.issn1873-6351
dc.identifier.urihttp://hdl.handle.net/10400.1/13016
dc.language.isoeng
dc.peerreviewedyes
dc.publisherPergamon-Elsevier Science Ltd
dc.subjectNeurodegenerative diseases
dc.subjectCholinesterase-inhibitors
dc.subjectOxidative stress
dc.subjectProtein
dc.subjectExtracts
dc.subjectDocking
dc.subjectPeptide
dc.titleJuncaceae species as sources of innovative bioactive compounds for the food industry: In vitro antioxidant activity, neuroprotective properties and in silico studies
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage596
oaire.citation.startPage590
oaire.citation.titleFood and Chemical Toxicology
oaire.citation.volume107
person.familyNameRodrigues
person.familyNameKatkam
person.familyNameVarela
person.familyNameBarreira
person.familyNameCustódio
person.givenNameMaria João
person.givenNameDr. Gangadhar
person.givenNameJoão
person.givenNameLuísa
person.givenNameLuísa
person.identifierR-004-VNG
person.identifier.ciencia-id2514-0E17-1D8D
person.identifier.ciencia-idB91F-5FD0-CB1C
person.identifier.ciencia-id6D1A-17E5-1400
person.identifier.ciencia-id791B-C560-AEA2
person.identifier.orcid0000-0001-8732-710X
person.identifier.orcid0000-0002-5368-5475
person.identifier.orcid0000-0003-3101-693X
person.identifier.orcid0000-0002-4077-855X
person.identifier.orcid0000-0003-4338-7703
person.identifier.ridM-4677-2013
person.identifier.ridM-4223-2013
person.identifier.ridM-6101-2013
person.identifier.scopus-author-id56031608100
person.identifier.scopus-author-id11638783300
person.identifier.scopus-author-id55741416000
person.identifier.scopus-author-id15831018900
rcaap.rightsrestrictedAccess
rcaap.typearticle
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