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Natural carriers for application in tuberculosis treatment

dc.contributor.authorCosta, Hugo
dc.contributor.authorGrenha, Ana
dc.date.accessioned2013-01-16T13:58:27Z
dc.date.available2013-01-16T13:58:27Z
dc.date.issued2012
dc.description.abstractTuberculosis remains the leading cause of preventable deaths worldwide and unsuccessful therapy is mainly due to non-compliance with very prolonged treatments, often associated with severe side-effects. Overcoming this problem demands the introduction of drug carriers releasing the antimicrobial agents in a targeted and sustained manner, allowing reduction in frequency and dosing numbers. Nano and microparticles have taken the forefront of this approach, providing the means for the desired improvement of therapeutic schedules. Natural polymers are strong candidates as matrix forming materials, usually exhibiting biocompatibility, biodegradability, low cost and some technological advantages as compared with synthetic counterparts. In this review, natural particulate carriers developed for tuberculosis therapy are presented, mainly focusing on the use of polysaccharides and lipids. Their effectiveness is discussed taking into account their composition. Finally, considerations on the general potential of natural materials for this application, as well as key factors still to be addressed, are discussed.por
dc.identifier.citationdoi:10.3109/02652048.2012.726283por
dc.identifier.issn0265-2048
dc.identifier.otherAUT: AMG02212;
dc.identifier.urihttp://hdl.handle.net/10400.1/2101
dc.language.isoengpor
dc.peerreviewedyespor
dc.subjectControlled releasepor
dc.subjectDrug deliverypor
dc.subjectMicroparticlespor
dc.subjectNanoparticlespor
dc.subjectMicroencapsulationpor
dc.titleNatural carriers for application in tuberculosis treatmentpor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage34por
oaire.citation.startPage1por
oaire.citation.titleJournal of Microencapsulationpor
person.familyNameGrenha
person.givenNameAna
person.identifier.ciencia-id091C-0D58-7225
person.identifier.orcid0000-0002-2136-1396
person.identifier.ridH-1392-2017
person.identifier.scopus-author-id8607930100
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication1bd4d8f1-40e5-45af-b1e8-4b8e73a6a70d
relation.isAuthorOfPublication.latestForDiscovery1bd4d8f1-40e5-45af-b1e8-4b8e73a6a70d

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