Repository logo
 
Publication

Evolution of GnRH ligands and receptors in gnathostomata

2006Journal article Restricted
Simple item page
dc.contributor.authorGuilgur, Leonardo G.
dc.contributor.authorMoncaut, Natalia P.
dc.contributor.authorCanario, Adelino V. M.
dc.contributor.authorSomoza, G. M.
dc.date.accessioned2014-05-09T09:36:35Z
dc.date.available2014-05-09T09:36:35Z
dc.date.issued2006
dc.date.updated2014-05-09T08:35:12Z
dc.description.abstractGonadotropin-releasing hormone (GnRH) is the final common signaling molecule used by the brain to regulate reproduction in all vertebrates. Until now, a total of 24 GnRH structural variants have been characterized from vertebrate, protochordate and invertebrate nervous tissue. Almost all vertebrates already investigated have at least two GnRH forms coexisting in the central nervous system. Furthermore, it is now well accepted that three GnRH forms are present both in early and late evolved teleostean fishes. The number and taxonomic distribution of the different GnRH variants also raise questions about the phylogenetic relationships between them. Most of the GnRH phylogenetic analyses are in agreement with the widely accepted idea that the GnRH family can be divided into three main groups. However, the examination of the gnathostome GnRH phylogenetic relationships clearly shows the existence of two main paralogous GnRH lineages: the ‘‘midbrain GnRH” group and the “forebrain GnRH” group. The first one, represented by chicken GnRH-II forms, and the second one composed of two paralogous lineages, the salmon GnRH cluster (only represented in teleostean fish species) and the hypophysotropic GnRH cluster, also present in tetrapods. This analysis suggests that the two forebrain clades share a common precursor and reinforces the idea that the salmon GnRH branch has originated from a duplication of the hypophysotropic lineage. GnRH ligands exert their activity through G protein-coupled receptors of the rhodopsin-like family. As with the ligands, multiple GnRHRs are expressed in individual vertebrate species and phylogenetic analyses have revealed that all vertebrate GnRHRs cluster into three main receptor types. However, new data and a new phylogenetic analysis propose a two GnRHR type model, in which different rounds of gene duplications may have occurred in different groups within each lineage.por
dc.identifier.citationGuilgur, Leonardo G.; Moncaut, Natalia P.; Canário, Adelino V.M.; Somoza, Gustavo M.Evolution of GnRH ligands and receptors in gnathostomata, Comparative Biochemistry and Physiology - Part A: Molecular & Integrative Physiology, 144, 3, 272-283, 2006.por
dc.identifier.doi10.1016/j.cbpa.2006.02.016
dc.identifier.issn1095-6433
dc.identifier.urihttp://hdl.handle.net/10400.1/3816
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevierpor
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S1095643306001334
dc.subjectGnRHpor
dc.subjectGnRH receptorspor
dc.subjectVertebratespor
dc.subjectEvolutionpor
dc.titleEvolution of GnRH ligands and receptors in gnathostomatapor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage283por
oaire.citation.issue3por
oaire.citation.startPage272por
oaire.citation.titleComparative Biochemistry and Physiology - Part A: Molecular and Integrative Physiologypor
oaire.citation.volume144por
person.familyNameCanario
person.givenNameAdelino
person.identifier143624
person.identifier.ciencia-id1F1E-D3B3-F804
person.identifier.orcid0000-0002-6244-6468
person.identifier.ridC-7942-2009
person.identifier.scopus-author-id56568523700
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication5f6e51ee-9113-469e-8b9e-f30f2d452521
relation.isAuthorOfPublication.latestForDiscovery5f6e51ee-9113-469e-8b9e-f30f2d452521

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Evolution of GnRH ligands and receptors in gnathostomata.pdf
Size:
312.04 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.61 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

CCM2-Artigos (em revistas ou actas indexadas)