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Proteínas gla do osso e cartilagem: importância dos anfíbios e peixes como modelos biológicos para elucidação da sua função e evolução - gla proteins in bone and cartilage: the importance of fish and amphibian models to understand their function and evolution

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dc.contributor.authorCancela, Leonor
dc.contributor.authorLaizé, Vincent
dc.contributor.authorSimes, D
dc.contributor.authorGavaia, Paulo J.
dc.contributor.authorConceição, N.
dc.contributor.authorS B Viegas, Carla
dc.contributor.authorPombinho, A. R.
dc.contributor.authorMarques, S.
dc.contributor.authorFidalgo, J.
dc.contributor.authorBraga, D.
dc.date.accessioned2014-06-19T08:42:47Z
dc.date.available2014-06-19T08:42:47Z
dc.date.issued2005
dc.description.abstractGla proteins, as the name indicates, undergo a post-translation modification where specific glutamic acid residues are γ-carboxylated through the action of the ubiquitous enzyme γ-carboxylase and using vitamin K as cofactor. Therefore, these proteins are also called vitamin K dependent proteins or VKD [1, 2]. We can assign VKDs to essentially four different groups: 1) those involved in blood coagulation (such as prothrombin and various coagulation factors; the first group to be discovered), 2) those involved in tissue mineralization (bone and matrix Gla proteins), 3) a nerve growth factor (gas6), and 4) those of unknown function (the latest group to be discovered). The carboxylase enzyme is present in fly and worm but not in yeast, indicating that γ-carboxylation is likely a feature appearing in multicellular eukaryotes.por
dc.identifier.citationM.L. Cancela, V. Laizé, D.C. Simes, P.J. Gavaia, N. Conceição,C. S. B. Viegas, A. R. Pombinho, S. M. P. Marques, J. Fidalgo, D. Braga 2005. Proteínas gla do osso e cartilagem: importância dos anfíbios e peixes como modelos biológicos para elucidação da sua função e evolução - gla proteins in bone and cartilage: the importance of fish and amphibian models to understand their function and evolution. 1º encontro o Mar e as Ciências da Saúde. April 21. Cooperativa Egas Moniz, Monte da Caparica, Portugal.por
dc.identifier.otherAUT: LCA00739; AUT: DSI00813
dc.identifier.urihttp://hdl.handle.net/10400.1/4398
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherCooperativa de Ensino Superior Egas Monizpor
dc.titleProteínas gla do osso e cartilagem: importância dos anfíbios e peixes como modelos biológicos para elucidação da sua função e evolução - gla proteins in bone and cartilage: the importance of fish and amphibian models to understand their function and evolutionpor
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceMonte da Caparicapor
oaire.citation.endPage8por
oaire.citation.startPage6por
oaire.citation.title1º encontro o Mar e as Ciências da Saúdepor
person.familyNameCancela
person.familyNameLaizé
person.familyNameSimes
person.familyNameGavaia
person.familyNameViegas
person.givenNameM. Leonor
person.givenNameVincent
person.givenNameDina
person.givenNamePaulo
person.givenNameCarla
person.identifier.ciencia-idB619-FC16-D007
person.identifier.ciencia-idC414-F596-EEC6
person.identifier.orcid0000-0003-3114-6662
person.identifier.orcid0000-0001-9565-9198
person.identifier.orcid0000-0002-5145-4753
person.identifier.orcid0000-0002-9582-1957
person.identifier.orcid0000-0002-5765-3665
person.identifier.ridB-4463-2008
person.identifier.ridN-2789-2014
person.identifier.ridA-6470-2011
person.identifier.ridN-6695-2014
person.identifier.scopus-author-id6602982778
person.identifier.scopus-author-id7201884723
person.identifier.scopus-author-id6507104377
person.identifier.scopus-author-id8656310300
rcaap.rightsrestrictedAccesspor
rcaap.typeconferenceObjectpor
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