Publicação
CYP27A1 expression in gilthead sea bream (Sparus auratus, L.): effects of calcitriol and parathyroid hormone-related protein
| dc.contributor.author | Bevelander, G. S. | |
| dc.contributor.author | Pinto, E. S. L. C. | |
| dc.contributor.author | Canario, Adelino V. M. | |
| dc.contributor.author | Spanings, T. | |
| dc.contributor.author | Flik, G. | |
| dc.date.accessioned | 2014-05-12T11:53:19Z | |
| dc.date.available | 2014-05-12T11:53:19Z | |
| dc.date.issued | 2008 | |
| dc.date.updated | 2014-05-08T11:06:10Z | |
| dc.description.abstract | Little is known about vitamin D metabolism in fishes. Several reports have shown hydroxylase activities in various organs to produce vitamin D metabolites, but the enzymes involved have not been isolated or characterized. We isolated and characterized a renal mitochondrial hydroxylase, CYP27A1, that governs vitamin D metabolism in gilthead sea bream, Sparus auratus. The enzyme is highly expressed in kidney and to a far lesser extent in liver. When treated with 25-hydroxy vitamin D or calcitriol, the kidney responded differentially and time dependently with CYP27A1 mRNA expression levels. This response substantiates a role for CYP27A1 in fish vitamin D metabolism. This notion is strengthened by upregulation of CYP27A1 in sea bream treated with parathyroid hormone-related protein (PTHrP), and suggests an original role for PTHrP in calcitriol-regulated processes n fish similar to the role of PTH in mammalian vitamin D-dependent processes. | por |
| dc.identifier.citation | Bevelander, G. S; Pinto, E. S L C; Canario, A. V M; Spanings, T.; Flik, G. CYP27A1 expression in gilthead sea bream (Sparus auratus, L.): effects of calcitriol and parathyroid hormone-related protein, Journal of Endocrinology, 196, 3, 625-635, 2008. | por |
| dc.identifier.doi | http://dx.doi.org/10.1677/JOE-07-0566 | |
| dc.identifier.issn | 0022-0795 | |
| dc.identifier.other | AUT: ACA00258; | |
| dc.identifier.uri | http://hdl.handle.net/10400.1/3863 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.publisher | Society for Endocrinology | por |
| dc.subject | D metabolism | por |
| dc.subject | Fishes | por |
| dc.title | CYP27A1 expression in gilthead sea bream (Sparus auratus, L.): effects of calcitriol and parathyroid hormone-related protein | por |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 635 | por |
| oaire.citation.issue | 3 | por |
| oaire.citation.startPage | 625 | por |
| oaire.citation.title | Journal of Endocrinology | por |
| oaire.citation.volume | 196 | por |
| person.familyName | Canario | |
| person.givenName | Adelino | |
| person.identifier | 143624 | |
| person.identifier.ciencia-id | 1F1E-D3B3-F804 | |
| person.identifier.orcid | 0000-0002-6244-6468 | |
| person.identifier.rid | C-7942-2009 | |
| person.identifier.scopus-author-id | 56568523700 | |
| rcaap.rights | restrictedAccess | por |
| rcaap.type | article | por |
| relation.isAuthorOfPublication | 5f6e51ee-9113-469e-8b9e-f30f2d452521 | |
| relation.isAuthorOfPublication.latestForDiscovery | 5f6e51ee-9113-469e-8b9e-f30f2d452521 |
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