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CYP27A1 expression in gilthead sea bream (Sparus auratus, L.): effects of calcitriol and parathyroid hormone-related protein

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dc.contributor.authorBevelander, G. S.
dc.contributor.authorPinto, E. S. L. C.
dc.contributor.authorCanario, Adelino V. M.
dc.contributor.authorSpanings, T.
dc.contributor.authorFlik, G.
dc.date.accessioned2014-05-12T11:53:19Z
dc.date.available2014-05-12T11:53:19Z
dc.date.issued2008
dc.date.updated2014-05-08T11:06:10Z
dc.description.abstractLittle is known about vitamin D metabolism in fishes. Several reports have shown hydroxylase activities in various organs to produce vitamin D metabolites, but the enzymes involved have not been isolated or characterized. We isolated and characterized a renal mitochondrial hydroxylase, CYP27A1, that governs vitamin D metabolism in gilthead sea bream, Sparus auratus. The enzyme is highly expressed in kidney and to a far lesser extent in liver. When treated with 25-hydroxy vitamin D or calcitriol, the kidney responded differentially and time dependently with CYP27A1 mRNA expression levels. This response substantiates a role for CYP27A1 in fish vitamin D metabolism. This notion is strengthened by upregulation of CYP27A1 in sea bream treated with parathyroid hormone-related protein (PTHrP), and suggests an original role for PTHrP in calcitriol-regulated processes n fish similar to the role of PTH in mammalian vitamin D-dependent processes.por
dc.identifier.citationBevelander, G. S; Pinto, E. S L C; Canario, A. V M; Spanings, T.; Flik, G. CYP27A1 expression in gilthead sea bream (Sparus auratus, L.): effects of calcitriol and parathyroid hormone-related protein, Journal of Endocrinology, 196, 3, 625-635, 2008.por
dc.identifier.doihttp://dx.doi.org/10.1677/JOE-07-0566
dc.identifier.issn0022-0795
dc.identifier.otherAUT: ACA00258;
dc.identifier.urihttp://hdl.handle.net/10400.1/3863
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherSociety for Endocrinologypor
dc.subjectD metabolismpor
dc.subjectFishespor
dc.titleCYP27A1 expression in gilthead sea bream (Sparus auratus, L.): effects of calcitriol and parathyroid hormone-related proteinpor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage635por
oaire.citation.issue3por
oaire.citation.startPage625por
oaire.citation.titleJournal of Endocrinologypor
oaire.citation.volume196por
person.familyNameCanario
person.givenNameAdelino
person.identifier143624
person.identifier.ciencia-id1F1E-D3B3-F804
person.identifier.orcid0000-0002-6244-6468
person.identifier.ridC-7942-2009
person.identifier.scopus-author-id56568523700
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication5f6e51ee-9113-469e-8b9e-f30f2d452521
relation.isAuthorOfPublication.latestForDiscovery5f6e51ee-9113-469e-8b9e-f30f2d452521

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