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Serenoa repens na hiperplasia benigna da próstata
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Abstract(s)
A hiperplasia benigna da próstata (HBP) constitui uma das condições urológicas mais comuns em homens de idade avançada, caracterizada pela proliferação de células estromais e epiteliais na zona de transição da próstata. Esta proliferação causa sintomas do trato urinário inferior, afetando negativamente a função sexual e na qualidade de vida. Embora a etiologia da HBP não seja totalmente compreendida, fatores como o aumento da dihidrotestosterona, inflamação, estrogénios, fatores genéticos, insulina e fatores de crescimento do tipo insulina estão implicados. A terapêutica da HBP visa reduzir a sintomatologia, melhorar a qualidade de vida do homem e prevenir o aparecimento de complicações. As opções terapêuticas variam de alterações comportamentais e no estilo de vida a tratamentos farmacológicos, incluindo antagonistas dos recetores adrenérgicos α1, inibidores da 5α-redutase, inibidores da fosfodiesterase-5, antagonistas dos recetores muscarínicos e agonistas beta-3. Em casos mais graves, poderá ser necessário intervenção cirúrgica. No entanto, estas terapias estão frequentemente associadas a efeitos adversos relacionados com a função sexual, especialmente em terapias combinadas, o que prejudica a sua adesão. Serenoa repens tem emergido como uma alternativa terapêutica eficaz e segura. Segundo estudos, o extrato de Serenoa repens tem demonstrado alguns benefícios na redução dos sintomas urinários, graças às suas propriedades anti-androgénicas, anti-inflamatórias, anti-proliferativas e pro-apoptóticas, contribuindo para o alívio dos sintomas e melhoria da qualidade de vida dos pacientes. Em comparação com os tratamentos convencionais, Serenoa repens demonstrou uma eficácia clínica semelhante e está associada a uma menor incidência de efeitos adversos, principalmente na função sexual, favorecendo a adesão à terapêutica. Os efeitos adversos mais comuns são gastrointestinais, mas geralmente são classificados como leves, autolimitados e reversíveis. Assim, Serenoa. repens surge como uma alternativa promissora no tratamento da HBP, particularmente em situações quando outras opções terapêuticas são limitadas ou apresentam efeitos adversos significativos e desconfortáveis para os pacientes.
Benign prostatic hyperplasia (BPH) is one of the most common urological conditions in older men, characterized by the proliferation of stromal and epithelial cells in the transition zone of the prostate. This proliferation causes lower urinary tract symptoms, which negatively affects sexual function and quality of life. Although the etiology of BPH is not fully understood, factors such as increased dihydrotestosterone, inflammation, estrogens, genetic factor, insulin, and insulin.like growth factors may be implicated. The treatment of BPH aims to reduce symptoms, improve the man´s quality of life, and prevent future complications. Therapeutic options range from behavioral and lifestyle modifications to pharmacological treatments, including α1-adrenergic receptor antagonists, 5-alpha-reductase inhibitors, phosphodiesterase-5 inhibitors, muscarinic receptor antagonists, and beta-3 agonists. In more severe cases, surgical interventions may be necessary. However, these therapies are often associated with adverse effects related to sexual functions, especially in combinations therapies, which hampers adherence to the pharmacological treatment. Serenoa repens has emerged as an effective and safe therapeutic alternative for BPH. According to several studies, Serenoa repens extract has shown significant benefits in reducing urinary symptoms, thanks to its anti-androgenic, anti-inflammatory, anti-proliferative, and pro-apoptotic properties, which contribute to symptom relief and improved patient quality of life. Compared to conventional treatments, Serenoa repens has demonstrated similar clinical efficacy and is associated with a lower incidence of adverse effects, particularly regarding sexual function, which favors adherence to therapy. The most common side effects are gastrointestinal but are generally classified as mild, self-limiting and reversible. Thus, Serenoa repens appears as a promising alternative therapy in the treatment of BPH, particularly in situations where other therapeutic options are limited or present significant and uncomfortable adverse reactions for patients.
Benign prostatic hyperplasia (BPH) is one of the most common urological conditions in older men, characterized by the proliferation of stromal and epithelial cells in the transition zone of the prostate. This proliferation causes lower urinary tract symptoms, which negatively affects sexual function and quality of life. Although the etiology of BPH is not fully understood, factors such as increased dihydrotestosterone, inflammation, estrogens, genetic factor, insulin, and insulin.like growth factors may be implicated. The treatment of BPH aims to reduce symptoms, improve the man´s quality of life, and prevent future complications. Therapeutic options range from behavioral and lifestyle modifications to pharmacological treatments, including α1-adrenergic receptor antagonists, 5-alpha-reductase inhibitors, phosphodiesterase-5 inhibitors, muscarinic receptor antagonists, and beta-3 agonists. In more severe cases, surgical interventions may be necessary. However, these therapies are often associated with adverse effects related to sexual functions, especially in combinations therapies, which hampers adherence to the pharmacological treatment. Serenoa repens has emerged as an effective and safe therapeutic alternative for BPH. According to several studies, Serenoa repens extract has shown significant benefits in reducing urinary symptoms, thanks to its anti-androgenic, anti-inflammatory, anti-proliferative, and pro-apoptotic properties, which contribute to symptom relief and improved patient quality of life. Compared to conventional treatments, Serenoa repens has demonstrated similar clinical efficacy and is associated with a lower incidence of adverse effects, particularly regarding sexual function, which favors adherence to therapy. The most common side effects are gastrointestinal but are generally classified as mild, self-limiting and reversible. Thus, Serenoa repens appears as a promising alternative therapy in the treatment of BPH, particularly in situations where other therapeutic options are limited or present significant and uncomfortable adverse reactions for patients.
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Keywords
eficácia clínica fitoterapia hiperplasia benigna da próstata próstata serenoa repens