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Early development of Neanderthals revealed through virtual microanatomy

2026-06-03Artigo científico Acesso aberto
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datacite.subject.sdg04:Educação de Qualidade
datacite.subject.sdg09:Indústria, Inovação e Infraestruturas
datacite.subject.sdg11:Cidades e Comunidades Sustentáveis
dc.contributor.authorMiszkiewicz, Justyna J.
dc.contributor.authorGodinho, Ricardo Miguel
dc.contributor.authorSohler-Snoddy, Anne Marie
dc.contributor.authorPasda, Kerstin
dc.contributor.authorDétroit, Florent
dc.contributor.authorMahoney, Patrick
dc.contributor.authorRathgeber, Thomas
dc.contributor.authorPosth, Cosimo
dc.contributor.authorUthmeier, Thorsten
dc.contributor.authorBarbieri, Alvise
dc.date.accessioned2026-07-02T16:55:44Z
dc.date.available2026-07-02T16:55:44Z
dc.date.issued2026-06-03
dc.description.abstractThe ontogeny of Neanderthal (Homo neanderthalensis) perinates is poorly understood due to the paucity of juvenile skeletal remains. Here we reconstruct fetal bone growth, and explore deciduous tooth structures, in three Neanderthal juveniles (Sesselfelsgrotte, 1, 2 and 3) (90 000–50 000 years ago) from southeastern Germany using non-invasive microcomputed tomography. Sesselfelsgrotte 1 exhibited bone tissue consistent with modern human perinatal plexiform-like structures and primary osteons. Long bones showed regions of advanced growth compared with the mandible and frontal bone, which can be explained through different processes of ossification and potentially localized faster development in Neanderthals compared with modern humans. Bone microstructure resembles that of the late third trimester of modern humans, agreeing with previous estimates based on macroscopic data. Sesselfelsgrotte 2 and 3 deciduous teeth retain hypodensities deep within the crown dentine consistent with interglobular dentine. We conclude that the fetal bone patterning is similar to modern humans with some areas of advanced growth, indicating that the growth trajectory for this Neanderthal perinate was broadly equivalent to that of modern humans. The abnormal dentine mineralization points towards a possible systemic disorder.eng
dc.description.sponsorship2023.10993.TENURE.006; 2022.07737.PTDC; 2002.08622.CEECIND
dc.identifier.doi10.1098/rsos.260485
dc.identifier.issn2054-5703
dc.identifier.urihttp://hdl.handle.net/10400.1/29205
dc.language.isoeng
dc.peerreviewedyes
dc.publisherThe Royal Society
dc.relation.ispartofRoyal Society Open Science
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectHomo neanderthalensis
dc.subjectOntogeny
dc.subjectMicro-CT
dc.subjectCortical bone
dc.subjectFetal growth
dc.subjectLife history
dc.subjectInterglobular dentine
dc.titleEarly development of Neanderthals revealed through virtual microanatomyeng
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumber2022.07737.PTDC
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/2022.07737.PTDC/PT
oaire.citation.issue6
oaire.citation.titleRoyal Society Open Science
oaire.citation.volume13
oaire.fundingStream3599-PPCDT
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameGodinho
person.familyNameBarbieri
person.givenNameRicardo Miguel
person.givenNameAlvise
person.identifier.ciencia-idE01A-0CC3-D631
person.identifier.ciencia-id2C14-231D-A989
person.identifier.orcid0000-0003-0107-9577
person.identifier.orcid0000-0002-4246-7691
person.identifier.ridP-2263-2015
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
relation.isAuthorOfPublication51a54f2c-0a51-4f8d-8791-529ffb1610e4
relation.isAuthorOfPublication280ba5be-60f4-4f4b-9710-641223b009fc
relation.isAuthorOfPublication.latestForDiscovery51a54f2c-0a51-4f8d-8791-529ffb1610e4
relation.isProjectOfPublication4002fe59-bf5d-40aa-b409-8597ef620e6e
relation.isProjectOfPublication.latestForDiscovery4002fe59-bf5d-40aa-b409-8597ef620e6e

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