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Does selective serotonin reuptake inhibitor (SSRI) fluoxetine affects mussel Mytilus galloprovincialis?

2013Journal article Open access
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dc.contributor.authorGonzalez-Rey, Maria
dc.contributor.authorBebianno, Maria João
dc.date.accessioned2019-01-28T11:52:57Z
dc.date.available2019-01-28T11:52:57Z
dc.date.issued2013
dc.description.abstractFluoxetine (FLX) the active pharmaceutical ingredient (API) in Prozac(®) is a widely prescribed psychoactive drug which ubiquitous occurrence in the aquatic environment is associated to a poor removal rate in waste-water treatment plant (WWTP) systems. This API acts as a selective serotonin reuptake inhibitor (SSRI) frequently reported to cause disrupting effects in non-target species. The objective of this study includes a multibiomarker response evaluation on mussel Mytilus galloprovincialis during two weeks exposure to 75 ng L(-1) FLX assessing antioxidant enzymes activities--superoxide dismutase (SOD), catalase (CAT) and glutathione-S-transferase (GST); lipid peroxidation (LPO), acetylcholinesterase (AChE) neurotoxic response and endocrine disruption through alkali-labile phosphates (ALP) indirect measurement of vitellogenin-like proteins. Results show transient tissue-specific enzymatic responses and damage affecting mostly mussel gills. However, the clear ALP levels inhibition throughout time in both sex-differentiated gonads gives evidence to FLX reinforced action as an endocrine disruptor rather than an oxidative or neurotoxic inducer.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.envpol.2012.10.018pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.1/12310
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationEFFECTS OF ACTIVE PHARMACEUTICAL RESIDUES IN MYTILUS GALLOPROVINCIALIS
dc.subjectAcetylcholinesterasept_PT
dc.subjectAnimalspt_PT
dc.subjectCatalasept_PT
dc.subjectEndocrine Disruptorspt_PT
dc.subjectFemalept_PT
dc.subjectFluoxetinept_PT
dc.subjectGlutathione Transferasept_PT
dc.subjectLipid Peroxidationpt_PT
dc.subjectMalept_PT
dc.subjectMytiluspt_PT
dc.subjectSuperoxide Dismutasept_PT
dc.subjectWater Pollutants, Chemicalpt_PT
dc.titleDoes selective serotonin reuptake inhibitor (SSRI) fluoxetine affects mussel Mytilus galloprovincialis?pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEFFECTS OF ACTIVE PHARMACEUTICAL RESIDUES IN MYTILUS GALLOPROVINCIALIS
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F41606%2F2007/PT
oaire.citation.endPage209pt_PT
oaire.citation.startPage200pt_PT
oaire.citation.titleEnvironmental Pollutionpt_PT
oaire.citation.volume173pt_PT
person.familyNameGonzalez-Rey
person.familyNameBebianno
person.givenNameMaria
person.givenNameMaria
person.identifier.ciencia-id2B11-46AC-B94B
person.identifier.orcid0000-0002-9343-8460
person.identifier.orcid0000-0003-1492-8566
person.identifier.scopus-author-id7004152715
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication182cc3b5-3e8d-4baf-9220-638978bef660
relation.isAuthorOfPublication2e00a26d-1dd3-4c22-a6bf-ac7943ae0d32
relation.isAuthorOfPublication.latestForDiscovery2e00a26d-1dd3-4c22-a6bf-ac7943ae0d32
relation.isProjectOfPublication8d64e32a-8e7e-4fd4-916c-5ab0994ec922
relation.isProjectOfPublication.latestForDiscovery8d64e32a-8e7e-4fd4-916c-5ab0994ec922

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