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Chemical composition, antibacterial screening and cytotoxic activity of Chiliadenus antiatlanticus (Asteraceae) essential oil

2021-06Journal article Restricted access
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dc.contributor.authorEl Yaagoubi, Mohamed
dc.contributor.authorOrtiz, Sergio
dc.contributor.authorMechqoq, Hicham
dc.contributor.authorCavaleiro, Carlos
dc.contributor.authorLecso-Bornet, Marylin
dc.contributor.authorRodrigues, Maria Joao
dc.contributor.authorCustódio, Luísa
dc.contributor.authorEl Mousadik, Abdelhamid
dc.contributor.authorGrougnet, Raphael
dc.contributor.authorEl Aouad, Noureddine
dc.contributor.authorMsanda, Fouad
dc.contributor.authorKritsanida, Marina
dc.date.accessioned2021-09-08T10:57:53Z
dc.date.available2021-09-08T10:57:53Z
dc.date.issued2021-06
dc.description.abstractThe chemical composition and in vitro antibacterial and cytotoxic activities of the essential oil (EO) of Chiliadenus antiatlanticus (Emb. & Maire) Gomiz, an asteraceous species endemic to the southwest of Morocco, were investigated. The EO yield was 1.07 +/- 0.28 %, twenty-seven metabolites were identified representing more than 96.4 % of the total composition. Camphor (35.7 %) and derivatives, borneol (4.9 %) and camphene (4.2 %) together with intermedeol (19.9 %), alpha-pinene (15.5 %) and (E)-pinocarveol (4.1 %) were the major constituents. An antibacterial activity was noticed against 24 strains (all Gram-positive) out of 71 at MICs values=100 mu g/mL. The EO also showed significant toxicity towards liver HepG2 (55.8 % of cell viability) and melanoma B16 4A5 (41.6 % of cell viability) tumor cell lines at 100 mu g/mL.
dc.description.sponsorshipUniversity of Paris; Ibn Zohr University; Fundacao para a Ciencia e a Tecnologia (FCT)Portuguese Foundation for Science and TechnologyEuropean Commission
dc.identifier.doi10.1002/cbdv.202100115
dc.identifier.issn1612-1872
dc.identifier.urihttp://hdl.handle.net/10400.1/16963
dc.language.isoeng
dc.peerreviewedyes
dc.publisherWILEY-V C H VERLAG GMBH
dc.relationExploitation of aromatic plants’ by-products for the development of novel cosmeceuticals and food supplements.
dc.subjectChiliadenus antiatlanticus
dc.subjectEssential oil
dc.subjectCamphor
dc.subjectIntermedeol
dc.subjectAntibacterial activity
dc.subject.otherBiochemistry & Molecular Biology; Chemistry
dc.titleChemical composition, antibacterial screening and cytotoxic activity of Chiliadenus antiatlanticus (Asteraceae) essential oil
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleExploitation of aromatic plants’ by-products for the development of novel cosmeceuticals and food supplements.
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/691247/EU
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/157544/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/PRAXIS XXI/4179/PT
oaire.citation.issue6
oaire.citation.titleChemistry & Biodiversity
oaire.citation.volume18
oaire.fundingStreamH2020
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamPRAXIS XXI
person.familyNameRodrigues
person.familyNameCustódio
person.givenNameMaria João
person.givenNameLuísa
person.identifierR-004-VNG
person.identifier.ciencia-id2514-0E17-1D8D
person.identifier.ciencia-id791B-C560-AEA2
person.identifier.orcid0000-0001-8732-710X
person.identifier.orcid0000-0003-4338-7703
person.identifier.ridM-6101-2013
person.identifier.scopus-author-id56031608100
person.identifier.scopus-author-id15831018900
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameEuropean Commission
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccess
rcaap.typearticle
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