Publication
Optimizing physicochemical properties of naturalantioxidants and geroprotectors: L-carnosine and melatonin
| datacite.subject.fos | Ciências Naturais::Ciências Químicas | pt_PT |
| dc.contributor.advisor | Grepioni, Fabrizia | |
| dc.contributor.advisor | Duarte, Teresa | |
| dc.contributor.author | Shemchuk, Oleksii | |
| dc.date.accessioned | 2016-03-14T16:06:00Z | |
| dc.date.available | 2016-03-14T16:06:00Z | |
| dc.date.issued | 2015-09-25 | |
| dc.date.submitted | 2015 | |
| dc.description | Dissertação de mestrado, Inovação Quimica e Regulamentação, Faculdade de Ciências e Tecnologia, Universidade do Algarve, 2015 | |
| dc.description.abstract | The issue of “Healthy Ageing” has become a significant challenge due to the continuous grow of World Population Ageing. Advancing health and well-being into old age and ensuring supportive environments is a main objective of NATO’s Department of Economic and Social Affairs Population Division [1]. Natural antioxidants such as L-carnosine and melatonin have been successfully used as geroprotectors. They reduce the risk of developing ageing-related diseases which is one the main aspects of healthy ageing. New formulation of the existing APIs is a widely used approach to optimize their physicochemical properties. Carnosine underwent reactions with a number of organic acids resulting in the discovery of seven new salts. The obtained salts were characterized by X-ray powder diffraction and thermal analyses. The structures were determined using X-ray Powder Diffraction (XRPD). The carnosine salts with glycolic and succinic acids might be of higher interest since both components possess antioxidant activity and carnosine, when used as a nutraceutical is usually combined with other antioxidants. Thus, the new formulation of carnosine as a salt with an acid possessing antioxidant activity can enhance its biological activity. Melatonin was co-crystallized with a number of coformers from various chemical groups. Two new co-crystals of melatonin with DABCO and piperazine were obtained by using mechanochemical technique (kneading). The structure of melatonin-DABCO co-crystal was established from a single crystal obtained by recrystallization from dichloromethane. The structure of melatonin-piperazine was solved using XRPD. Though only one of the obtained co-crystals can find a direct application in Pharmaceutical industry (DABCO does not belong to the GRAS list), our results confirm the reactivity of melatonin in co-crystallization processes, and emphasizes the need to continue the search for an improved formulation. | pt_PT |
| dc.description.sponsorship | European Commission: scholarship funded within the Erasmus+ KA1 Programme, ref. 2013-0241 - Erasmus Mundus Joint Master Degree in Chemical Innovation and Regulation | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.1/7849 | |
| dc.language.iso | eng | pt_PT |
| dc.subject | Antioxidantes | pt_PT |
| dc.subject | Engenharia dos cristais | pt_PT |
| dc.subject | L-carnosina | pt_PT |
| dc.subject | Melatonina | pt_PT |
| dc.title | Optimizing physicochemical properties of naturalantioxidants and geroprotectors: L-carnosine and melatonin | pt_PT |
| dc.type | master thesis | |
| dspace.entity.type | Publication | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | masterThesis | pt_PT |
| thesis.degree.grantor | Universidade do Algarve. Faculdade de Ciências e Tecnologia | |
| thesis.degree.level | Mestre | |
| thesis.degree.name | Mestrado em Inovação Quimica e Regulamentação | pt_PT |