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Publication
Nanotecnologia aplicada à dermofarmácia
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Advisor(s)
Abstract(s)
A pele é um órgão multifuncional e, como tal, apresenta-se como uma das
principais vias para a entrega de fármacos. A aplicação cutânea de substâncias
proporciona um efeito mais ou menos profundo, com efeitos sistémicos
geralmente reduzidos. No entanto, o maior órgão do corpo humano constitui uma
barreira notável à entrada e saída de substâncias e, por este motivo, a
permeabilidade cutânea continua a ser um desafio difícil de combater, que só é
conseguido através da preparação de formulações capazes de a superar. Para
tentar colmatar esse problema, a nanotecnologia foi introduzida para a otimização
das formulações já existentes e, no campo farmacêutico, os sistemas
nanoparticulados têm sido utilizados como veículos de fármacos com o objetivo de
solucionar alguns problemas relacionados com a biodisponibilidade, estabilidade e
toxicidade.
A utilização da nanotecnologia na dermofarmácia tem sido relevante para o
tratamento de algumas doenças cutâneas, evitando os efeitos adversos associados
às terapêuticas sistémicas. Contudo, é unânime a necessidade de uma avaliação
mais aprofundada na área da toxicologia, com o objetivo de permitir uma melhor
previsão dos seus efeitos na saúde.
Com esta monografia pretende-se, então, enfatizar a relevância da nanotecnologia
na área da dermofarmácia, mais concretamente para o tratamento da psoríase e
dermatite atópica, no processo de cicatrização e regeneração de feridas e, por fim,
no envelhecimento.
The skin is a multifunctional organ and, as such, presents itself as one of the main routes for drug delivery. The application of substances in the skin provides a more or less profound effect with generally reduced systemic effects. However, the largest organ in the human body, is a remarkable barrier to the entry and escape of substances and, therefore, skin permeability remains a difficult challenge to tackle, and only can be achieved by preparing formulations that can overcome it. To address this problem, nanotechnology has been introduced to optimize existing formulations and, in the pharmaceutical field, nanoparticulate systems have been used as drug carriers to address some problems related to bioavailability, stability and toxicity. The use of nanotechnology in dermopharmacy has been relevant for the treatment of some skin diseases, avoiding the adverse effects associated with systemic therapies. However, the need for further evaluation in the field of toxicology is unanimous with a view to better predicting its effects on health. The purpose of this monograph is to emphasize the relevance of nanotechnology in dermopharmacy area, specifically for the treatment of psoriasis and atopic dermatitis, wound healing and regeneration and, finally, aging.
The skin is a multifunctional organ and, as such, presents itself as one of the main routes for drug delivery. The application of substances in the skin provides a more or less profound effect with generally reduced systemic effects. However, the largest organ in the human body, is a remarkable barrier to the entry and escape of substances and, therefore, skin permeability remains a difficult challenge to tackle, and only can be achieved by preparing formulations that can overcome it. To address this problem, nanotechnology has been introduced to optimize existing formulations and, in the pharmaceutical field, nanoparticulate systems have been used as drug carriers to address some problems related to bioavailability, stability and toxicity. The use of nanotechnology in dermopharmacy has been relevant for the treatment of some skin diseases, avoiding the adverse effects associated with systemic therapies. However, the need for further evaluation in the field of toxicology is unanimous with a view to better predicting its effects on health. The purpose of this monograph is to emphasize the relevance of nanotechnology in dermopharmacy area, specifically for the treatment of psoriasis and atopic dermatitis, wound healing and regeneration and, finally, aging.
Description
Keywords
Cicatrização e regeneração Dermatite atópica Envelhecimento Nanotecnologia Pele Psoríase.