Publication
Photosensitizers for photodynamic therapy: One-pot heterogeneous catalytic transfer reduction of porphyrins
| dc.contributor.author | Fernandes, A. | |
| dc.contributor.author | Rosa da Costa, Ana | |
| dc.contributor.author | Serra, Arménio C. | |
| dc.contributor.author | Pires, Catarina | |
| dc.date.accessioned | 2015-09-08T09:26:01Z | |
| dc.date.available | 2015-09-08T09:26:01Z | |
| dc.date.issued | 2011-04 | |
| dc.description.abstract | A number of new porphyrin-based photosensitizers have been developed for Photodynamic Therapy (PDT) in recent years. Chlorins, which are a reduced form of porphyrins, show better potential of application since they have a stronger absorption band on the red region of the visible spectrum and, hence, a deeper penetration into tissues. We found that by using heterogeneous catalytic transfer reduction (CTR), meso-tetraphenylporphyrin (TPP) could be hydrogenated, although in modest yields, to meso-tetraphenylchlorin (TPC) in a single reaction step. Best reaction conditions were attained using formic acid or sodium phosphinate/water as hydrogen donors, tetrahydrofuran (THF) or toluene as solvent and 10% palladium on charcoal as catalyst. | por |
| dc.identifier.citation | J Pharm Bioall Sci 2011;3:294-7 | por |
| dc.identifier.doi | 10.4103/0975-7406.80770 | |
| dc.identifier.issn | 0976-4879 | |
| dc.identifier.other | AUT: AMC01695; ABR00608; | |
| dc.identifier.uri | http://hdl.handle.net/10400.1/6739 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.publisher | Medknow | por |
| dc.relation.publisherversion | http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2011;volume=3;issue=2;spage=294;epage=297;aulast=Brigas | por |
| dc.subject | Catalytic transfer reduction | por |
| dc.subject | hydrogenation | por |
| dc.subject | Meso-tetraphenylchlorin | por |
| dc.subject | Meso-tetraphenylporphyrin | por |
| dc.subject | Photosensitizers | por |
| dc.title | Photosensitizers for photodynamic therapy: One-pot heterogeneous catalytic transfer reduction of porphyrins | por |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 297 | por |
| oaire.citation.issue | 2 | por |
| oaire.citation.startPage | 294 | por |
| oaire.citation.title | Journal of Pharmacy and BioAllied Sciences | por |
| oaire.citation.volume | 3 | por |
| person.familyName | Rosa da Costa | |
| person.givenName | Ana M | |
| person.identifier | 305029 | |
| person.identifier.ciencia-id | A418-A85E-5DB1 | |
| person.identifier.orcid | 0000-0003-0225-9537 | |
| person.identifier.rid | E-2165-2012 | |
| person.identifier.scopus-author-id | 53986075100 | |
| rcaap.rights | restrictedAccess | por |
| rcaap.type | article | por |
| relation.isAuthorOfPublication | 0ca8c16f-6881-4662-bafc-cc51c5ce8d88 | |
| relation.isAuthorOfPublication.latestForDiscovery | 0ca8c16f-6881-4662-bafc-cc51c5ce8d88 |
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