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Publicação
Photosensitizers for photodynamic therapy: One-pot heterogeneous catalytic transfer reduction of porphyrins
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Orientador(es)
Resumo(s)
A number of new porphyrin-based photosensitizers have been developed for Photodynamic Therapy (PDT) in
recent years. Chlorins, which are a reduced form of porphyrins, show better potential of application since they
have a stronger absorption band on the red region of the visible spectrum and, hence, a deeper penetration into
tissues. We found that by using heterogeneous catalytic transfer reduction (CTR), meso-tetraphenylporphyrin
(TPP) could be hydrogenated, although in modest yields, to meso-tetraphenylchlorin (TPC) in a single reaction
step. Best reaction conditions were attained using formic acid or sodium phosphinate/water as hydrogen
donors, tetrahydrofuran (THF) or toluene as solvent and 10% palladium on charcoal as catalyst.
Descrição
Palavras-chave
Catalytic transfer reduction hydrogenation Meso-tetraphenylchlorin Meso-tetraphenylporphyrin Photosensitizers
Contexto Educativo
Citação
J Pharm Bioall Sci 2011;3:294-7
Editora
Medknow