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Microfluidic Organ/Body-on-a-Chip Devices at the Convergence of Biology and Microengineering

2015-12Journal article Open access
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dc.contributor.authorPerestrelo, Ana Rubina
dc.contributor.authorÁguas, Ana C. P.
dc.contributor.authorRainer, Alberto
dc.contributor.authorForte, Giancarlo
dc.date.accessioned2018-12-07T14:52:46Z
dc.date.available2018-12-07T14:52:46Z
dc.date.issued2015-12
dc.description.abstractRecent advances in biomedical technologies are mostly related to the convergence of biology with microengineering. For instance, microfluidic devices are now commonly found in most research centers, clinics and hospitals, contributing to more accurate studies and therapies as powerful tools for drug delivery, monitoring of specific analytes, and medical diagnostics. Most remarkably, integration of cellularized constructs within microengineered platforms has enabled the recapitulation of the physiological and pathological conditions of complex tissues and organs. The so-called organ-on-a-chip technology, which represents a new avenue in the field of advanced in vitro models, with the potential to revolutionize current approaches to drug screening and toxicology studies. This review aims to highlight recent advances of microfluidic-based devices towards a body-on-a-chip concept, exploring their technology and broad applications in the biomedical field.
dc.description.sponsorshipEuropean Regional Development Fund-Project FNUSA-ICRC [CZ.1.05/1.1.00/02.0123]; Fundacao para a Ciencia e a Tecnologia (FCT), Portugal [UID/BIM/04773/2013]; Internal Research Grant Program, Universita Campus Bio-Medico di Roma
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.3390/s151229848
dc.identifier.issn1424-8220
dc.identifier.urihttp://hdl.handle.net/10400.1/11205
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI Ag
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCirculating tumor-cells
dc.subjectIn-Vitro model
dc.subjectReal-time Pcr
dc.subjectStem-cells
dc.subjectCancer patients
dc.subjectBreast-cancer
dc.subjectGene-expression
dc.subjectLabel-free
dc.subjectCapillary-Electrophoresis
dc.subjectEpithelial-cells
dc.titleMicrofluidic Organ/Body-on-a-Chip Devices at the Convergence of Biology and Microengineering
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FBIM%2F04773%2F2013/PT
oaire.citation.endPage31170
oaire.citation.issue12
oaire.citation.startPage31142
oaire.citation.titleSensors
oaire.citation.volume15
oaire.fundingStream5876
person.familyNameÁguas
person.givenNameAna
person.identifier.orcid0000-0002-1575-6367
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
rcaap.typearticle
relation.isAuthorOfPublication23a1460a-af80-48b4-9699-e75fbe2f5a07
relation.isAuthorOfPublication.latestForDiscovery23a1460a-af80-48b4-9699-e75fbe2f5a07
relation.isProjectOfPublicatione13142f2-37b8-4b5a-b2cd-352e62003184
relation.isProjectOfPublication.latestForDiscoverye13142f2-37b8-4b5a-b2cd-352e62003184

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