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Impact of age, gender and body mass index on the efficacy of tranexamic acid in total knee arthroplasty
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Advisor(s)
Abstract(s)
Background: Tranexamic acid (TXA) is effective and safe in decreasing blood loss and transfusion rate in total knee
arthroplasty (TKA). Few studies focused on the role of patients’ characteristics on the efficacy of TXA in TKA. The
purpose of this study was to conduct a retrospective analysis to investigate if age, gender and BMI influence the
efficacy of TXA in reducing perioperative blood loss in TKA.
Methods: We did an observational study including 366 consecutive patients undergoing TKA in Hospital Particular
do Algarve between January 2011 and April 2019 which were divided in two groups: intraoperative administration of
intravenous TXA (TXA Group) and no administration of TXA (Control Group). The perioperative blood loss between
groups and their relation with age, gender and BMI was compared.
Results: Of the 366 patients, 225 (61%) received TXA. In both groups, age did not correlate to the blood loss.
Women in the TXA group had less perioperative blood loss than in the control group. No such difference was found
for men. The normal weight group showed no difference in perioperative blood loss with or without TXA
administration. However, there was a statistically significant difference in the overweight and obese groups. The
mean perioperative blood loss was higher in the control group (854±342 ml) than in the TXA group (720±335 ml).
Conclusions: TXA administration is efficient in controlling TKA associated hemorrhage in overweight and obese
individuals and in women but it doesn’t have that effect in normal weight patients or in men.
Description
Keywords
Age Body mass index Blood loss Gender Tranexamic acid Total knee arthroplasty
Citation
Publisher
Medip Academy