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Impact of age, gender and body mass index on the efficacy of tranexamic acid in total knee arthroplasty

2020-08-26Journal article Open access
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dc.contributor.authorViegas, Rui
dc.contributor.authorKumar, Abhishek
dc.contributor.authorCarvalho, Maria M.
dc.contributor.authorVide, João
dc.contributor.authorFontes, Ana Paula
dc.contributor.authorSousa, João P.
dc.date.accessioned2022-07-21T10:32:32Z
dc.date.available2022-07-21T10:32:32Z
dc.date.issued2020-08-26
dc.date.updated2022-07-20T16:53:21Z
dc.description.abstractBackground: Tranexamic acid (TXA) is effective and safe in decreasing blood loss and transfusion rate in total knee arthroplasty (TKA). Few studies focused on the role of patients’ characteristics on the efficacy of TXA in TKA. The purpose of this study was to conduct a retrospective analysis to investigate if age, gender and BMI influence the efficacy of TXA in reducing perioperative blood loss in TKA. Methods: We did an observational study including 366 consecutive patients undergoing TKA in Hospital Particular do Algarve between January 2011 and April 2019 which were divided in two groups: intraoperative administration of intravenous TXA (TXA Group) and no administration of TXA (Control Group). The perioperative blood loss between groups and their relation with age, gender and BMI was compared. Results: Of the 366 patients, 225 (61%) received TXA. In both groups, age did not correlate to the blood loss. Women in the TXA group had less perioperative blood loss than in the control group. No such difference was found for men. The normal weight group showed no difference in perioperative blood loss with or without TXA administration. However, there was a statistically significant difference in the overweight and obese groups. The mean perioperative blood loss was higher in the control group (854±342 ml) than in the TXA group (720±335 ml). Conclusions: TXA administration is efficient in controlling TKA associated hemorrhage in overweight and obese individuals and in women but it doesn’t have that effect in normal weight patients or in men.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.18203/issn.2455-4510.intjresorthop20203710pt_PT
dc.identifier.issn2455-4510
dc.identifier.slugcv-prod-2485451
dc.identifier.urihttp://hdl.handle.net/10400.1/18053
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMedip Academypt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAgept_PT
dc.subjectBody mass indexpt_PT
dc.subjectBlood losspt_PT
dc.subjectGenderpt_PT
dc.subjectTranexamic acidpt_PT
dc.subjectTotal knee arthroplastypt_PT
dc.titleImpact of age, gender and body mass index on the efficacy of tranexamic acid in total knee arthroplastypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage887pt_PT
oaire.citation.issue5pt_PT
oaire.citation.startPage884pt_PT
oaire.citation.titleInternational Journal of Research in Orthopaedicspt_PT
oaire.citation.volume6pt_PT
person.familyNamede Almeida Fontes
person.givenNameAna Paula
person.identifier.ciencia-id6E12-B4BA-87AF
person.identifier.orcid0000-0002-4431-5229
rcaap.cv.cienciaid6E12-B4BA-87AF | Ana Paula de Almeida Fontes
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication00fe72a3-c82a-4726-bd5d-efeb7fb59650
relation.isAuthorOfPublication.latestForDiscovery00fe72a3-c82a-4726-bd5d-efeb7fb59650

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