Repository logo
 
Publication

The secretin G-protein-coupled receptor family: teleost receptors

2005Journal article Restricted access
Simple item page
dc.contributor.authorCardoso, João CR
dc.contributor.authorClark, M. S.
dc.contributor.authorVieira, Florbela A.
dc.contributor.authorBridge, P. D.
dc.contributor.authorGilles, A.
dc.contributor.authorPower, Deborah
dc.date.accessioned2014-10-24T12:26:32Z
dc.date.available2014-10-24T12:26:32Z
dc.date.issued2005
dc.description.abstractTwenty-one members of the secretin family (family 2) of G-protein-coupled receptors (GPCRs) were identified via directed cloning and data-mining of the Fugu Genome Consortium database, representing the most comprehensive description of secretin GPCRs in a teleost fish to date. Duplicated genes were identified for many of the family members, namely the receptors for pituitary adenylate cyclase-activating polypeptide (PACAP)/vasoactive intestinal peptide (VIP), calcitonin, calcitonin gene-related peptide (CGRP), growth hormone releasing hormone (GHRH), glucagon receptor/glucagon-like peptide (GLP) and parathyroid hormone-related peptide (PTHrP)/PTH. Mining of other teleost genomes (zebrafish and Tetraodon) revealed that the duplicated genes identified in the Takifugu genome were also present in these fish. Additional database searching of the Escherichia coli, yeast, Drosophila, Caenorhabditis elegans and Ciona genomes revealed that the family 2 of GPCRs were only present in the multicellular organisms. Orthologues of all the human secretin receptors were identified with the exception of secretin itself. Additional database searches in the Fugu Genome Consortium database also failed to reveal a secretin ligand and so it is hypothesised that both the receptor and the ligand evolved after the divergence of teleost/tetrapod lineages. Phylogenetic analysis at both the protein and the DNA level provided strong support for each of the individual receptor family groupings, but weak support between groups, making evolutionary inferences difficult. A more critical analysis of the PACAP/VIP receptor family confirmed previous hypotheses that the vasoactive intestinal peptide receptor (VPAC1R) gene is the ancestral form of the receptor.por
dc.description.sponsorshipThis work was supported by a FCT plurianual grant to Centro de Cieˆncias do Mar do Algarve (CCMAR), Portugal. J C R Cardoso was funded by FCT, Portugal (grant BD/19925/99). This paper was produced by MSC within the LATEST core programme.por
dc.identifier.citationJ C R Cardoso, M S Clark, F A Viera, P D Bridge, A Gilles and D M Power, "The secretin G-protein-coupled receptor family: teleost receptors" in Journal of Molecular Endocrinology (2005) 34, 753–765.por
dc.identifier.doihttp://dx.doi.org/10.1677/jme.1.01730
dc.identifier.issn0952-5041
dc.identifier.otherAUT: DPO00386;
dc.identifier.urihttp://hdl.handle.net/10400.1/5476
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherBioScientificapor
dc.titleThe secretin G-protein-coupled receptor family: teleost receptorspor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage765por
oaire.citation.startPage735por
oaire.citation.titleJournal of Molecular Endocrinologypor
oaire.citation.volume34por
person.familyNameCardoso
person.familyNamePower
person.givenNameJoão
person.givenNameDeborah Mary
person.identifier14332
person.identifier.ciencia-id8B16-F203-2AFC
person.identifier.ciencia-id891A-8A44-3CAE
person.identifier.orcid0000-0001-7890-0170
person.identifier.orcid0000-0003-1366-0246
person.identifier.ridM-4151-2013
person.identifier.scopus-author-id7201822956
person.identifier.scopus-author-id7101806760
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication1b670c84-15e3-4776-8871-50f9eb0eed0d
relation.isAuthorOfPublicationc68f5ffb-63f6-4c70-8957-29e464fb59c0
relation.isAuthorOfPublication.latestForDiscoveryc68f5ffb-63f6-4c70-8957-29e464fb59c0

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
The secretin G-protein-coupled receptor family Teleost receptors.pdf
Size:
176.59 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
3.49 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

CCM2-Artigos (em revistas ou actas indexadas)