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Design and synthesis of novel 2-pyridone peptidomimetic falcipain 2/3 inhibitors

2008Journal article Restricted access
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dc.contributor.authorVerissimo, Edite
dc.contributor.authorBerry, Neil
dc.contributor.authorGibbons, Peter D.
dc.contributor.authorCristiano, Maria Lurdes Santos
dc.contributor.authorRosenthal, Philip J.
dc.contributor.authorGut, Jiri
dc.contributor.authorWard, Stephen A.
dc.contributor.authorO'Neill, Paul M.
dc.date.accessioned2014-06-06T14:31:38Z
dc.date.available2014-06-06T14:31:38Z
dc.date.issued2008
dc.date.updated2014-06-05T11:19:37Z
dc.description.abstractThe structure-based design, chemical synthesis and in vitro activity evaluation of various falcipain inhibitors derived from 2-pyridone are reported. These compounds contain a peptidomimetic binding determinant and a Michael acceptor terminal moiety capable of deactivating the cysteine protease active site.por
dc.identifier.citationVerissimo, Edite; Berry, Neil; Gibbons, Peter; Cristiano, M. Lurdes S.; Rosenthal, Philip J.; Gut, Jiri; Ward, Stephen A.; O’Neill, Paul M. Design and synthesis of novel 2-pyridone peptidomimetic falcipain 2/3 inhibitors, Bioorganic & Medicinal Chemistry Letters, 18, 14, 4210-4214, 2008.por
dc.identifier.doihttp://dx.doi.org/10.1016/j.bmcl.2008.05.068
dc.identifier.issn0960-894X
dc.identifier.otherAUT: MCR00716;
dc.identifier.urihttp://hdl.handle.net/10400.1/4221
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevierpor
dc.subjectMalariapor
dc.subjectPlasmodium falciparumpor
dc.subjectCysteine proteasepor
dc.subjectFalcipain-2por
dc.subjectPeptidomimeticpor
dc.titleDesign and synthesis of novel 2-pyridone peptidomimetic falcipain 2/3 inhibitorspor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage4214por
oaire.citation.issue14por
oaire.citation.startPage4210por
oaire.citation.titleBioorganic & Medicinal Chemistry Letterspor
oaire.citation.volume18por
person.familyNameVerissimo
person.familyNameCristiano
person.givenNameEdite
person.givenNameMaria de Lurdes
person.identifier.ciencia-idE411-6006-5A01
person.identifier.orcid0000-0003-0352-5446
person.identifier.orcid0000-0002-9447-2855
person.identifier.ridG-2345-2012
person.identifier.scopus-author-id9238724800
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication2f678005-d8fb-4cf4-8cd0-0d15f464b9c1
relation.isAuthorOfPublicationb16751a6-748e-44b0-9c59-058cbd5b2cc3
relation.isAuthorOfPublication.latestForDiscovery2f678005-d8fb-4cf4-8cd0-0d15f464b9c1

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