Design and synthesis of novel 2-pyridone peptidomimetic falcipain 2/3 inhibitors

Verissimo, Edite; Berry, Neil; Gibbons, Peter D.; Cristiano, Maria Lurdes Santos; Rosenthal, Philip J.; Gut, Jiri; Ward, Stephen A.; O'Neill, Paul M.

http://hdl.handle.net/10400.1/4221

Utilize este identificador para referenciar este registo.

Nome:	Descrição:	Tamanho:	Formato:
Design and synthesis of novel 2-pyridone peptidomimetic falcipain 2 3 inhibitors.pdf		285.14 KB	Adobe PDF	Ver/Abrir

Contacte-nos

Autores

Verissimo, Edite

Berry, Neil

Gibbons, Peter D.

Cristiano, Maria Lurdes Santos

Resumo(s)

The structure-based design, chemical synthesis and in vitro activity evaluation of various falcipain inhibitors derived from 2-pyridone are reported. These compounds contain a peptidomimetic binding determinant and a Michael acceptor terminal moiety capable of deactivating the cysteine protease active site.

Palavras-chave

Malaria Plasmodium falciparum Cysteine protease Falcipain-2 Peptidomimetic

URI

http://hdl.handle.net/10400.1/4221

Citação

Verissimo, Edite; Berry, Neil; Gibbons, Peter; Cristiano, M. Lurdes S.; Rosenthal, Philip J.; Gut, Jiri; Ward, Stephen A.; O’Neill, Paul M. Design and synthesis of novel 2-pyridone peptidomimetic falcipain 2/3 inhibitors, Bioorganic & Medicinal Chemistry Letters, 18, 14, 4210-4214, 2008.

Editora

Elsevier

DOI

http://dx.doi.org/10.1016/j.bmcl.2008.05.068

Coleções

CCM2-Artigos (em revistas ou actas indexadas)

Métricas Alternativas

Ver registo completo