Publication
Chitosan/carrageenan nanoparticles: effect of cross-linking with tripolyphosphate
| dc.contributor.author | Rodrigues, Susana | |
| dc.contributor.author | Costa, Ana M. Rosa da | |
| dc.contributor.author | Grenha, Ana | |
| dc.date.accessioned | 2013-01-16T13:23:33Z | |
| dc.date.available | 2013-01-16T13:23:33Z | |
| dc.date.issued | 2012 | |
| dc.description.abstract | Chitosan/carrageenan/tripolyphosphate nanoparticles were prepared by polyelectrolyte complexation/ionic gelation, the latter compound acting as cross-linker. The incorporation of the three components in the nanoparticle matrix was assessed by analytical techniques (FTIR, XPS and TOF-SIMS). Using chitosan/carrageenan nanoparticles as control, the effect of the cross-linker in the particles properties was studied. A decrease in size (from 450-500 nm to 150-300 nm) and in zeta potential (from +75 - +85 mV to +50 - +60 mV), and an increase in production yield (from 15-20% to 25-35%), and in stability (from one week to up to 9 months) were observed. Also, a correlation between positive to negative charge ratios in the formulations and the above characteristics was established. The small size and high positive surface charge make the developed chitosan/carrageenan/tripolyphosphate nanoparticles potential tools for an application in mucosal delivery of macromolecules. | por |
| dc.identifier.issn | 0144-8617 | |
| dc.identifier.other | AUT: AMC01695; | |
| dc.identifier.uri | http://hdl.handle.net/10400.1/2086 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.subject | Chitosan | por |
| dc.subject | Cross-linking | por |
| dc.subject | Carrageenan | por |
| dc.subject | Nanoparticles | por |
| dc.subject | Tripolyphosphate | por |
| dc.title | Chitosan/carrageenan nanoparticles: effect of cross-linking with tripolyphosphate | por |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 289 | por |
| oaire.citation.startPage | 282 | por |
| oaire.citation.title | Carbohydrate Polymers | por |
| oaire.citation.volume | 89 | por |
| person.familyName | Rodrigues | |
| person.familyName | Rosa da Costa | |
| person.familyName | Grenha | |
| person.givenName | Susana | |
| person.givenName | Ana M | |
| person.givenName | Ana | |
| person.identifier | 305029 | |
| person.identifier.ciencia-id | 9D1A-6537-0383 | |
| person.identifier.ciencia-id | A418-A85E-5DB1 | |
| person.identifier.ciencia-id | 091C-0D58-7225 | |
| person.identifier.orcid | 0000-0002-0329-4265 | |
| person.identifier.orcid | 0000-0003-0225-9537 | |
| person.identifier.orcid | 0000-0002-2136-1396 | |
| person.identifier.rid | E-2165-2012 | |
| person.identifier.rid | H-1392-2017 | |
| person.identifier.scopus-author-id | 55125292100 | |
| person.identifier.scopus-author-id | 53986075100 | |
| person.identifier.scopus-author-id | 8607930100 | |
| rcaap.rights | openAccess | por |
| rcaap.type | article | por |
| relation.isAuthorOfPublication | f7e806c8-708d-4caf-9b95-cfe9f3b06e8e | |
| relation.isAuthorOfPublication | 0ca8c16f-6881-4662-bafc-cc51c5ce8d88 | |
| relation.isAuthorOfPublication | 1bd4d8f1-40e5-45af-b1e8-4b8e73a6a70d | |
| relation.isAuthorOfPublication.latestForDiscovery | 0ca8c16f-6881-4662-bafc-cc51c5ce8d88 |
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