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Vitamin K as a powerful micronutrient in aging and age-related diseases: pros and cons from clinical studies

2019Journal article Open access
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dc.contributor.authorSimes, Dina
dc.contributor.authorViegas, Carla
dc.contributor.authorAraujo, Nuna C. P.
dc.contributor.authorMarreiros, C.
dc.date.accessioned2019-11-13T15:33:33Z
dc.date.available2019-11-13T15:33:33Z
dc.date.issued2019
dc.description.abstractVitamin K is a multifunctional micronutrient implicated in age-related diseases such as cardiovascular diseases, osteoarthritis and osteoporosis. Although vitamin K-dependent proteins (VKDPs) are described to have a crucial role in the pathogenesis of these diseases, novel roles have emerged for vitamin K, independently of its role in VKDPs carboxylation. Vitamin K has been shown to act as an anti-inflammatory by suppressing nuclear factor κB (NF-κB) signal transduction and to exert a protective effect against oxidative stress by blocking the generation of reactive oxygen species. Available clinical evidences indicate that a high vitamin K status can exert a protective role in the inflammatory and mineralization processes associated with the onset and progression of age-related diseases. Also, vitamin K involvement as a protective super-micronutrient in aging and 'inflammaging' is arising, highlighting its future use in clinical practice. In this review we summarize current knowledge regarding clinical data on vitamin K in skeletal and cardiovascular health, and discuss the potential of vitamin K supplementation as a health benefit. We describe the clinical evidence and explore molecular aspects of vitamin K protective role in aging and age-related diseases, and its involvement as a modulator in the interplay between pathological calcification and inflammation processes.pt_PT
dc.description.sponsorshipAgência financiadora Portuguese Society of Nephrology (SPN) Portuguese national funds from FCT-Foundation for Science and Technology UID/Multi/04326/2019pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/ijms20174150
dc.identifier.issn1422-0067
dc.identifier.urihttp://hdl.handle.net/10400.1/12882
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectVitamin Kpt_PT
dc.subjectVitamin K-dependent proteinspt_PT
dc.subjectCardiovascular diseasespt_PT
dc.subjectSkeletal healthpt_PT
dc.subjectInflammagingpt_PT
dc.subjectPathological calcificationpt_PT
dc.subjectInflammationpt_PT
dc.titleVitamin K as a powerful micronutrient in aging and age-related diseases: pros and cons from clinical studiespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue17pt_PT
oaire.citation.startPage4150pt_PT
oaire.citation.titleInternational Journal of Molecular Sciencespt_PT
oaire.citation.volume20pt_PT
person.familyNameSimes
person.familyNameViegas
person.familyNameAraujo
person.familyNameMARREIROS
person.givenNameDina
person.givenNameCarla
person.givenNameNuna
person.givenNameCATARINA
person.identifier.ciencia-idC414-F596-EEC6
person.identifier.ciencia-idB116-E70E-EB2A
person.identifier.orcid0000-0002-5145-4753
person.identifier.orcid0000-0002-5765-3665
person.identifier.orcid0000-0002-7602-0150
person.identifier.ridN-2789-2014
person.identifier.ridN-6695-2014
person.identifier.ridN-8531-2013
person.identifier.scopus-author-id7201884723
person.identifier.scopus-author-id8656310300
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication31bac96d-1d01-4b8f-8f2b-9da4be31ea41
relation.isAuthorOfPublication33984b3c-ffac-477a-896a-ddbf7aced4e3
relation.isAuthorOfPublication3423e71b-934d-4da7-9c81-4e56c7930252
relation.isAuthorOfPublicationfcb4a0e0-0a88-4582-946e-eda31694c02c
relation.isAuthorOfPublication.latestForDiscovery31bac96d-1d01-4b8f-8f2b-9da4be31ea41

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