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A validação do multiple sclerosis neuropsychological questionnaire para a população portuguesa
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Abstract(s)
Este estudo teve como objetivo avaliar as propriedades psicométricas da versão portuguesa do Multiple Sclerosis Neuropsychological Questionnaire (MSNQ), um instrumento usado para medir queixas cognitivas subjetivas em pessoas com Esclerose Múltipla (PcEM). A amostra incluiu 54 pacientes com EM, com idades entre 18 e 59 anos, e 33 informantes, recrutados de um centro especializado em Lisboa. Foram aplicados testes neuropsicológicos e questionários emocionais, como a HADS, além das duas versões do MSNQ: uma de autorrelato (MSNQ-P) e outra preenchida por informantes (MSNQ-I).
A análise fatorial por componentes principais revelou uma estrutura bifatorial para ambas as versões do MSNQ, com a versão do informante mostrando melhor correlação com medidas objetivas de cognição, enquanto o MSNQ-P se correlacionou mais com variáveis emocionais, como a depressão. A análise da curva ROC revelou que o MSNQ-I teve uma capacidade de discriminação moderada, com uma área sob a curva de 0,78, sensibilidade de 0,92 e especificidade de 0,67. No entanto, o MSNQ-P não foi capaz de discriminar de forma eficaz entre pacientes com e sem défices cognitivos.
Conclui-se que a versão portuguesa do MSNQ-I é uma ferramenta confiável para a identificação de défices cognitivos em PcEM, enquanto o MSNQ-P deve ser utilizado com cautela, especialmente em pacientes com alterações emocionais. Sugere-se que a integração das perceções dos pacientes e informantes com medidas objetivas e emocionais proporciona uma avaliação mais robusta e abrangente, com impacto positivo na prática clínica.
This study aimed to evaluate the psychometric properties of the Portuguese version of the Multiple Sclerosis Neuropsychological Questionnaire (MSNQ), an instrument used to measure subjective cognitive complaints in individuals with Multiple Sclerosis (MS). The sample included 54 MS patients, aged between 18 and 59 years, and 33 informants, recruited from a specialized centre in Lisbon. Neuropsychological tests and emotional questionnaires, such as the HADS, were administered along with both versions of the MSNQ: a self-report (MSNQ-P) and an informant-rated version (MSNQ-I). Principal component analysis revealed a bifactorial structure for both MSNQ versions, with the informant version showing a better correlation with objective cognitive measures, while the MSNQ-P was more closely related to emotional variables, such as depression. ROC curve analysis demonstrated that the MSNQ-I had moderate discriminatory ability, with an area under the curve of 0.78, sensitivity of 0.92, and specificity of 0.67. However, the MSNQ-P was ineffective in distinguishing between patients with and without cognitive deficits. In conclusion, the Portuguese version of the MSNQ-I is a reliable tool for identifying cognitive deficits in MS patients. At the same time, the MSNQ-P should be used cautiously, especially in patients with emotional alterations. It is suggested that integrating patients' and informants' perceptions with objective and emotional measures provides a more robust and comprehensive evaluation, benefiting clinical practice.
This study aimed to evaluate the psychometric properties of the Portuguese version of the Multiple Sclerosis Neuropsychological Questionnaire (MSNQ), an instrument used to measure subjective cognitive complaints in individuals with Multiple Sclerosis (MS). The sample included 54 MS patients, aged between 18 and 59 years, and 33 informants, recruited from a specialized centre in Lisbon. Neuropsychological tests and emotional questionnaires, such as the HADS, were administered along with both versions of the MSNQ: a self-report (MSNQ-P) and an informant-rated version (MSNQ-I). Principal component analysis revealed a bifactorial structure for both MSNQ versions, with the informant version showing a better correlation with objective cognitive measures, while the MSNQ-P was more closely related to emotional variables, such as depression. ROC curve analysis demonstrated that the MSNQ-I had moderate discriminatory ability, with an area under the curve of 0.78, sensitivity of 0.92, and specificity of 0.67. However, the MSNQ-P was ineffective in distinguishing between patients with and without cognitive deficits. In conclusion, the Portuguese version of the MSNQ-I is a reliable tool for identifying cognitive deficits in MS patients. At the same time, the MSNQ-P should be used cautiously, especially in patients with emotional alterations. It is suggested that integrating patients' and informants' perceptions with objective and emotional measures provides a more robust and comprehensive evaluation, benefiting clinical practice.
Description
Keywords
Esclerose múltipla Défice cognitivo Avaliação neuropsicológica Queixas subjetivas Depressão