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Volt-ampere characteristics of porcine retinal Muller cell intermediate filaments

2020-01Journal article Open access
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dc.contributor.authorMakarov, Vladimir
dc.contributor.authorKhmelinskii, Igor
dc.date.accessioned2021-06-24T11:36:10Z
dc.date.available2021-06-24T11:36:10Z
dc.date.issued2020-01
dc.description.abstractIn the current study we reported current-voltage (I/V) characteristics of Muller cell (MC) intermediate filaments (IFs) isolated from porcine retina. It was found that the measured I/V dependences demonstrate behavior of a semiconductor in contact with metal (Au) electrodes. The analysis of the temperature dependence of the experimental I/V curves produced estimates of the parameter values characterizing the electrical conductivity properties of the studied MC IFs. The I/V characteristics and the parameter values allowed to describe the MC IFs as a semiconducting material. The observed properties clarify the mechanism of high-contrast daylight vision of vertebrate eyes. This mechanism was extensively discussed earlier, and is directly dependent on the electric conductivity properties of MC IFs. Significance Statement: Retinal cones and rods are physically connected to glial Muller cells by intermediate filaments (IFs). Electric conductivity of IFs allows for a simple quantum mechanical description of light energy transmission through the retina, providing a convincing mechanism that achieves high-contrast vision in vertebrate eyes. Note that classic light transmission is hindered by light scattering on the retinal structures. Electric conductivity of IFs also opens the possibility for energy exchange within and between other cell types by way of IFs and microtubules, and the possibility that such structures may be used for signaling e.g. in the nervous system.
dc.description.sponsorshipInstitute for Functional Nanomaterials (NSF Grant) [1002410]
dc.description.sponsorshipPR NASA EPSCoR (NASA Cooperative Agreement) [NNX15AK43A]
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1016/j.chemphys.2019.110532
dc.identifier.issn0301-0104
dc.identifier.urihttp://hdl.handle.net/10400.1/16651
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectPorcine retina
dc.subjectMuller cell
dc.subjectIntermediate filament
dc.subjectLight energy transmission
dc.subjectLight energy guide
dc.titleVolt-ampere characteristics of porcine retinal Muller cell intermediate filaments
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage110532
oaire.citation.titleChemical Physics
oaire.citation.volume528
person.familyNameKhmelinskii
person.givenNameIgor
person.identifier0000000420541031
person.identifier.ciencia-id0D1A-CB6C-6316
person.identifier.orcid0000-0002-6116-184X
person.identifier.ridC-9587-2011
person.identifier.scopus-author-id6701444934
rcaap.rightsopenAccess
rcaap.typearticle
relation.isAuthorOfPublicationfcb9f09f-2e99-41fb-8c08-7e1acbc65076
relation.isAuthorOfPublication.latestForDiscoveryfcb9f09f-2e99-41fb-8c08-7e1acbc65076

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