Loading...
Publication
Fitoterapia no tratamento da patologia da gota
| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| 33.42 MB | Adobe PDF |
Authors
Advisor(s)
Abstract(s)
A gota é uma doença reumática desencadeada pela resposta inflamatória à deposição e
acumulação de cristais de monourato de sódio, que se pode desenvolver em indivíduos com
níveis séricos elevados de ácido úrico (hiperuricémia) devido à sua superprodução ou deficiente
eliminação renal e ou intestinal. Para que seja considerado gota, e não apenas hiperuricemia,
exige a manifestação dos sintomas típicos da resposta inflamatória.
Nas últimas décadas é possível verificar um aumento da prevalência da gota. Atinge
entre 1-4 % dos adultos em todo o mundo e em Portugal, estima-se que afete 1,6% da nossa
população.
Apesar da inquestionável eficácia das alternativas terapêuticas existentes atualmente no
mercado farmacêutico, a evidência científica descortinou efeitos adversos severos. Em
contrapartida, a comunidade científica alega a existência de um leque diversificado de plantas
com aplicação quer na prevenção quer no tratamento da gota, seja pelo seu uso empírico, seja
porque a sua efetividade foi avaliada in vitro e/ou in vivo, baseando-se no seu potencial de
inibição sobre a xantina oxidase (XO), na sua ação uricosúrica ou pelo seu efeito antiinflamatório
e antioxidante.
O presente trabalho que é uma revisão bibliográfica com recurso a ferramentas como a
PubMed e a guidelines terapêuticas indicadas para a gota, começa pela definição, evolução
histórica, classificação, epidemiologia, patogenia e manifestações clínicas desta patologia. De
seguida, apresenta a terapia convencional geralmente dirigida para a gota, focando-se depois
nos estudos que utilizam as plantas, quer em estudos in vitro quer em estudos in vivo, com
potencial ação farmacológica nesta doença. O contributo do farmacêutico no tratamento da gota
é igualmente abordado bem como a necessidade da farmacovigilância em Produtos à Base de
Plantas.
Gout, a rheumatic disease prompt by the inflammatory response to an accumulation of sodium monourate, can start to develop in patients with a high serum of uric acid levels (Hyperuricemia) due to your super-production or a deficient elimination by the kidneys or intestine. To be diagnosed with Gout and not just Hyperuricemia, the patient has to have the common symptoms of inflammation. In the last decades, it is possible to verify a rise in the spread of Gout. It hits 1 to 4 percent of the adult population in the World. In Portugal, the statistics show an estimated 1,6 percent of the population. Despite the undoubted efficiency of the alternative therapeutics currently in the pharmaceutical market, the scientific evidence showed severe side effects. On the other side, the scientific community claims the existence of a diversified range of plants that applied in the treatment and prevention of Gout, by your empirical use, and this has been tested and evaluated in vitro and in vivo, based on the inhibition of xanthine oxidase (XO), in their uricosuric action and/or by your effect antioxidant and anti-inflammatory. This paper is a bibliographic revision that has used PubMed and therapeutic guidelines as a base, especially regarding the treatment of Gout that starts with the definition, historic evolution, classification epidemiologic, pathogenesis and clinical manifestations of this pathology. It will also show the current conventional therapy used in the treatment of Gout and it will focus on the published studies that use plants and their potential application as a treatment, these studies are in vitro as well in vivo. The contribution of the pharmacist in the treatment of gout is also addressed, as well as the need for pharmacovigilance in plant based products.
Gout, a rheumatic disease prompt by the inflammatory response to an accumulation of sodium monourate, can start to develop in patients with a high serum of uric acid levels (Hyperuricemia) due to your super-production or a deficient elimination by the kidneys or intestine. To be diagnosed with Gout and not just Hyperuricemia, the patient has to have the common symptoms of inflammation. In the last decades, it is possible to verify a rise in the spread of Gout. It hits 1 to 4 percent of the adult population in the World. In Portugal, the statistics show an estimated 1,6 percent of the population. Despite the undoubted efficiency of the alternative therapeutics currently in the pharmaceutical market, the scientific evidence showed severe side effects. On the other side, the scientific community claims the existence of a diversified range of plants that applied in the treatment and prevention of Gout, by your empirical use, and this has been tested and evaluated in vitro and in vivo, based on the inhibition of xanthine oxidase (XO), in their uricosuric action and/or by your effect antioxidant and anti-inflammatory. This paper is a bibliographic revision that has used PubMed and therapeutic guidelines as a base, especially regarding the treatment of Gout that starts with the definition, historic evolution, classification epidemiologic, pathogenesis and clinical manifestations of this pathology. It will also show the current conventional therapy used in the treatment of Gout and it will focus on the published studies that use plants and their potential application as a treatment, these studies are in vitro as well in vivo. The contribution of the pharmacist in the treatment of gout is also addressed, as well as the need for pharmacovigilance in plant based products.
Description
Keywords
Gota Fitoterapia Ácido urico Hiperuricemia