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CRTAC1 homolog proteins are conserved from cyanobacteria to man and secreted by the teleost fish pituitary gland

2010Journal article Restricted access
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dc.contributor.authorRedruello, Begoña
dc.contributor.authorLouro, Bruno
dc.contributor.authorAnjos, Liliana
dc.contributor.authorSilva, Nádia
dc.contributor.authorGreenwell, Roger S.
dc.contributor.authorCanario, Adelino V. M.
dc.contributor.authorPower, Deborah
dc.date.accessioned2014-05-19T10:22:19Z
dc.date.available2014-05-19T10:22:19Z
dc.date.issued2010
dc.date.updated2014-05-08T10:20:15Z
dc.description.abstractCartilage acidic protein 1 (CRTAC1) gene expression is used as a marker for chondrocyte differentiation instem cell-based tissue engineering. It is also transcribed outside the skeleton where at least two different transcripts are expressed in lung and brain. In the pituitary gland of the teleost fish sea bream Sparus auratus, we have found a transcript with a high degree of sequence identity to CRTAC1 family members but lacking the EGF-like calcium-binding domain encoding sequence of CRTAC1 and designated it as CRTAC2. Database searches revealed many previously unidentified members of the CRTAC1 and CRTAC2 in phylogenetically distant organisms, such as cyanobacteria, bryophyta, lancelets, and diverse representatives of vertebrates. Phylogenetic analyses showed that the genes encoding CRTAC1 and CRTAC2 proteins coexist in teleost fish genomes. Structural prediction analysis identified the N-terminal region of the CRTAC1/CRTAC2 family members as a potential seven-bladed β -propeller structure, closely related to those of integrin α chains and glycosylphosphatidylinositol-specific phospholipase D1 protein families. This relationship is con fi rmed by phylogenetic analysis with the N-terminal domain of sea bream CRTAC2 as the most divergent sequence. Because teleost fi shes are the only phylogenetic group where both CRTAC1 and CRTAC2 genes are present, they occupy a pivotal position in studies of the mechanisms governing the speci fi c expression patterns of each gene/protein subfamily. This will be essential to elucidate their respective biological roles.por
dc.identifier.citationRedruello, Begoña; Louro, Bruno; Anjos, Liliana; Silva, Nádia; Greenwell, Roger S.; Canario, Adelino V.M.; Power, Deborah M.CRTAC1 homolog proteins are conserved from cyanobacteria to man and secreted by the teleost fish pituitary gland, Gene, 456, 1-2, 1-14, 2010.por
dc.identifier.issn03781119
dc.identifier.otherAUT: ACA00258
dc.identifier.otherAUT: DPO00386
dc.identifier.urihttp://hdl.handle.net/10400.1/3996
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevierpor
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S0378111910000612por
dc.subjectExtracellular matrixpor
dc.subjectIntegrin αpor
dc.subjectβ -Propellerpor
dc.subjectCartilage acidic protein 1por
dc.subjectEGF-like calcium-binding domainpor
dc.titleCRTAC1 homolog proteins are conserved from cyanobacteria to man and secreted by the teleost fish pituitary glandpor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage14por
oaire.citation.issue1-2por
oaire.citation.startPage1por
oaire.citation.titleGenepor
oaire.citation.volume456por
person.familyNameRedruello
person.familyNameLouro
person.familyNameAnjos Guerreiro
person.familyNameSilva
person.familyNameCanario
person.familyNamePower
person.givenNameBegoña
person.givenNameBruno
person.givenNameLiliana Isabel Tomé
person.givenNameNádia
person.givenNameAdelino
person.givenNameDeborah Mary
person.identifierAAK-3800-2020
person.identifier143624
person.identifier.ciencia-id6D18-2D1C-A45C
person.identifier.ciencia-id5D1F-6F3A-A1C2
person.identifier.ciencia-id1F1E-D3B3-F804
person.identifier.ciencia-id891A-8A44-3CAE
person.identifier.orcid0000-0003-1787-5594
person.identifier.orcid0000-0001-8164-581X
person.identifier.orcid0000-0001-9474-522X
person.identifier.orcid0000-0001-9881-4421
person.identifier.orcid0000-0002-6244-6468
person.identifier.orcid0000-0003-1366-0246
person.identifier.ridC-7942-2009
person.identifier.scopus-author-id16028940200
person.identifier.scopus-author-id8575757700
person.identifier.scopus-author-id10244362100
person.identifier.scopus-author-id56568523700
person.identifier.scopus-author-id7101806760
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
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