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The effect of food deprivation and refeeding on the liver, thyroid hormones and transthyretin in sea bream

2000Journal article Restricted access
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dc.contributor.authorPower, Deborah
dc.contributor.authorMelo, J.
dc.contributor.authorSantos, C. R. A.
dc.date.accessioned2014-10-23T14:14:51Z
dc.date.available2014-10-23T14:14:51Z
dc.date.issued2000
dc.description.abstractThere was a significant reduction in body weight of sea bream Sparus aurata and the hepatosomatic index after 3 weeks food deprivation. Liver biochemical indices and morphology were altered by food deprivation, there was a loss of eosin staining in hepatocyte cytoplasm and the appearance of large depleted vacuoles. Cell and nuclear area were significantly reduced (P<0·001) and did not return to control values after 1 week of refeeding. The water, lipid, glycogen and protein content of the liver was significantly reduced by 3 weeks fasting but recovered rapidly after 1 week refeeding. Food restriction also had a marked effect on circulating thyroid hormones and the concentration of plasma T3 (33·98 12·47 ng ml 1) and T4 (16·54 9·5 ng ml 1) was significantly (P<0·001) lower than the control (66·52 13·4 and 56·83 7·3, respectively). Refeeding for 1 week restored circulating T3 (P<0·05) close to control levels but did not significantly affect the concentration of T4. Northern blotting with an homologous probe for transthyretin (TTR) demonstrated clearly the expression of a single mRNA transcript of 0·7 kb for this protein in the liver. The level of TTR message was substantially reduced below control levels in the liver of fasted fish and 1 week refeeding failed to restore expression.por
dc.identifier.citationDeborah Power, J. Melo e C.R.A. Santos, "The effect of food deprivation and refeeding on the liver, thyroid hormones and transthyretin in sea bream" in Journal of Fish Biology (2000) 56, 374–387.por
dc.identifier.doihttp://dx.doi.org/10.1006/jfbi.1999.1165
dc.identifier.doidoi: 10.1006/jfbi.1999.116
dc.identifier.otherAUT: DPO00386;
dc.identifier.urihttp://hdl.handle.net/10400.1/5429
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherWileypor
dc.relation.publisherversionhttp://onlinelibrary.wiley.com/doi/10.1111/j.1095-8649.2000.tb02112.x/abstractpor
dc.subjectEnergy reservespor
dc.subjectFood restritctionpor
dc.subjectRefeedingpor
dc.subjectLiverpor
dc.subjectThyroid hormonespor
dc.subjectTransthyretinpor
dc.titleThe effect of food deprivation and refeeding on the liver, thyroid hormones and transthyretin in sea breampor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage387por
oaire.citation.issue2
oaire.citation.startPage374por
oaire.citation.titleJournal of Fish Biologypor
oaire.citation.volume56por
person.familyNamePower
person.givenNameDeborah Mary
person.identifier.ciencia-id891A-8A44-3CAE
person.identifier.orcid0000-0003-1366-0246
person.identifier.scopus-author-id7101806760
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublicationc68f5ffb-63f6-4c70-8957-29e464fb59c0
relation.isAuthorOfPublication.latestForDiscoveryc68f5ffb-63f6-4c70-8957-29e464fb59c0

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