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Fish allergy management: from component-resolved diagnosis to unmet diagnostic needs

2019-10Journal article Open access
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dc.contributor.authorKlueber, Julia
dc.contributor.authorSchrama, Denise
dc.contributor.authorRodrigues, Pedro
dc.contributor.authorDickel, Heinrich
dc.contributor.authorKuehn, Annette
dc.date.accessioned2020-07-28T10:52:28Z
dc.date.available2020-07-28T10:52:28Z
dc.date.issued2019-10
dc.description.abstractPurpose of review Fish is a common elicitor of IgE-mediated food allergy. Fish includes a large variety of foods, in terms of species and food processing, with marked distinction in local diets around the globe. Fish-allergic patients present with phenotypic diversity and major differences in levels of clinical cross-reactivity, features that pose an important challenge for the clinical diagnosis and management. Recent findings Parvalbumin is the major fish allergen. However, a single molecule is not sufficient but several homologs, allergens different from parvalbumin and allergen extracts, are needed for IgE-based diagnosis. Summary Parvalbumin-specific IgE are markers for clinical cross-reactions. Added value is provided by IgE typing to parvalbumin homologs from distantly related fish. IgE cosensitization profiles (parvalbumin, enolase, aldolase) are referred as severity markers. The allergen panel seems to be not yet complete why fish extracts still play a crucial role inserum IgE analysis. Further clinical validation of a multiplex approach in molecular fish allergy diagnosis is needed for striving to avoid unnecessary food restrictions and in a further sense, improved patient care.pt_PT
dc.description.sponsorshipMinistry of Research, Luxembourg (JK, AK), the PRIDE program grant (PRIDE/11012546/NEXTIMMUNE) ;Fonds National de la Recherche (FNR), Luxembourg (JK, AK) and the Personalized Medicine Consortium Luxembourg (JK, AK). This work received national funds through FCT - Foundation for Science and Technology through project UID/Multi/04326/2019. FCT PhD grant SFRH/BD/136319/2018.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.issn2196-3053
dc.identifier.urihttp://hdl.handle.net/10400.1/14532
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAllergenpt_PT
dc.subjectComponent-resolved diagnosispt_PT
dc.subjectFish allergypt_PT
dc.subjectFoodpt_PT
dc.subjectParvalbuminpt_PT
dc.titleFish allergy management: from component-resolved diagnosis to unmet diagnostic needspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage337pt_PT
oaire.citation.issue6pt_PT
oaire.citation.startPage322pt_PT
oaire.citation.titleCurrent Treatment Options in Allergypt_PT
person.familyNameSchrama
person.familyNameRodrigues
person.givenNameDenise
person.givenNamePedro
person.identifier159154
person.identifier.ciencia-id501C-AC69-68C0
person.identifier.orcid0000-0003-0274-5957
person.identifier.orcid0000-0002-9668-1204
person.identifier.ridH-6511-2016
person.identifier.ridM-3406-2013
person.identifier.scopus-author-id55755583400
person.identifier.scopus-author-id55107531000
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication00f4fa6e-b467-4d5c-83f2-a454f7b4bc71
relation.isAuthorOfPublicationc4613fe6-e1a0-4dd9-be8d-442b2b8a7b72
relation.isAuthorOfPublication.latestForDiscoveryc4613fe6-e1a0-4dd9-be8d-442b2b8a7b72

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