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Shedding light on the hidden benefit of Porphyridium cruentum culture

2023-01-31Journal article Open access
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dc.contributor.authorLiberti, Davide
dc.contributor.authorImbimbo, Paola
dc.contributor.authorGiustino, Enrica
dc.contributor.authorD’Elia, Luigi
dc.contributor.authorSilva, Mélanie
dc.contributor.authorBarreira, Luísa
dc.contributor.authorMonti, Daria Maria
dc.date.accessioned2023-02-27T10:08:51Z
dc.date.available2023-02-27T10:08:51Z
dc.date.issued2023-01-31
dc.date.updated2023-02-24T14:08:02Z
dc.description.abstractMicroalgae can represent a reliable source of natural compounds with different activities. Here, we evaluated the antioxidant and anti-inflammatory activity of sulfated exopolysaccharides (s-EPSs) and phycoerythrin (PE), two molecules naturally produced by the red marine microalga Porphyridium cruentum (CCALA415). In vitro and cell-based assays were performed to assess the biological activities of these compounds. The s-EPSs, owing to the presence of sulfate groups, showed biocompatibility on immortalized eukaryotic cell lines and a high antioxidant activity on cell-based systems. PE showed powerful antioxidant activity both in vitro and on cell-based systems, but purification is mandatory for its safe use. Finally, both molecules showed anti-inflammatory activity comparable to that of ibuprofen and helped tissue regeneration. Thus, the isolated molecules from microalgae represent an excellent source of antioxidants to be used in different fields.pt_PT
dc.description.sponsorshipUIDP/0436/2020
dc.description.sponsorshipLA/P/0101/2020
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAntioxidants 12 (2): 337 (2023)pt_PT
dc.identifier.doi10.3390/antiox12020337pt_PT
dc.identifier.eissn2076-3921
dc.identifier.urihttp://hdl.handle.net/10400.1/19131
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationAlgarve Centre for Marine Sciences
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectMicroalgaept_PT
dc.subjectExopolysaccharidespt_PT
dc.subjectPhycoerythrinpt_PT
dc.subjectAntioxidant activitypt_PT
dc.subjectAnti-inflammatory activitypt_PT
dc.subjectBiocompatibilitypt_PT
dc.subjectWound healingpt_PT
dc.titleShedding light on the hidden benefit of Porphyridium cruentum culturept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04326%2F2020/PT
oaire.citation.issue2pt_PT
oaire.citation.startPage337pt_PT
oaire.citation.titleAntioxidantspt_PT
oaire.citation.volume12pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameSilva
person.familyNameBarreira
person.givenNameMélanie
person.givenNameLuísa
person.identifier.ciencia-id6D1A-17E5-1400
person.identifier.orcid0000-0002-0460-646X
person.identifier.orcid0000-0002-4077-855X
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication73171e04-28cb-41f1-9750-ad5327b6e673
relation.isAuthorOfPublicationce3d77be-25df-4257-b5b3-aca8cff24116
relation.isAuthorOfPublication.latestForDiscoveryce3d77be-25df-4257-b5b3-aca8cff24116
relation.isProjectOfPublicationfafa76a6-2cd2-4a6d-a3c9-772f34d3b91f
relation.isProjectOfPublication.latestForDiscoveryfafa76a6-2cd2-4a6d-a3c9-772f34d3b91f

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