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Bioaccessibility of lipophilic and hydrophilic marine biotoxins in seafood: an in vitro digestion approach

2019Journal article Open Access
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dc.contributor.authorAlves, Ricardo N.
dc.contributor.authorRambla-Alegre, Maria
dc.contributor.authorBraga, Ana Catarina
dc.contributor.authorMaulvault, Ana L.
dc.contributor.authorBarbosa, Vera
dc.contributor.authorCampàs, Mònica
dc.contributor.authorReverté, Laia
dc.contributor.authorFlores, Cintia
dc.contributor.authorCaixach, Josep
dc.contributor.authorKilcoyne, Jane
dc.contributor.authorCosta, Pedro Reis
dc.contributor.authorDiogène, Jorge
dc.contributor.authorMarques, António
dc.date.accessioned2020-07-31T16:13:04Z
dc.date.available2020-07-31T16:13:04Z
dc.date.issued2019
dc.description.abstractThis study aimed to assess the bioaccessibility of different marine biotoxins in naturally contaminated shellfish and fish gonads using an in vitro digestion methodology. In general, hydrophilic toxins (domoic acid, paralytic shellfish poisoning toxins and tetrodotoxins) showed higher bioaccessibility than lipophilic ones (okadaic acid and azaspiracids). The bioaccessibility of toxins from the okadaic acid group ranged from 69% (raw European razor clams) to 74% (raw donax clams). Regarding azaspiracids, 47% of the initial content was bioaccessible in steamed blue mussel. As for hydrophilic toxins, 100% of the initial content was bioaccessible after digestion in raw shellfish and puffer fish gonads. The total tetrodotoxin bioaccessibility in puffer fish gonads decreased significantly after steaming. The profile of tetrodotoxins changed during the digestion process: TTX and 11-norTTX-6S-ol analogues decreased significantly after digestion, but the 5,6,11-trideoxy TTX analogue increased in both raw and steamed puffer fish gonads. These preliminary findings confirm the need to consider bioaccessibility data in future seafood risk assessment, as such information enables a more accurate and realistic estimation of potential seafood hazards, particularly in what concerns lipophilic toxins, therefore, constituting a crucial tool in the refinement of regulatory limits for the presence of biotoxins in seafood.pt_PT
dc.description.sponsorshipFCT - PD/BD/113484/2015pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.fct.2019.04.041pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.1/14567
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationPriority environmental contaminants in seafood: safety assessment, impact and public perception
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAnimalspt_PT
dc.subjectBiological availabilitypt_PT
dc.subjectHumanspt_PT
dc.subjectHydrophobic and hydrophilic interactionspt_PT
dc.subjectSeafoodpt_PT
dc.subjectSeawaterpt_PT
dc.subjectToxins, biologicalpt_PT
dc.titleBioaccessibility of lipophilic and hydrophilic marine biotoxins in seafood: an in vitro digestion approachpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitlePriority environmental contaminants in seafood: safety assessment, impact and public perception
oaire.awardURIinfo:eu-repo/grantAgreement/EC/FP7/311820/EU
oaire.citation.endPage161pt_PT
oaire.citation.startPage153pt_PT
oaire.citation.titleFood and Chemical Toxicologypt_PT
oaire.citation.volume129pt_PT
oaire.fundingStreamFP7
person.familyNameReis Costa
person.givenNamePedro
person.identifier600820
person.identifier.ciencia-idC911-9715-E547
person.identifier.orcid0000-0001-6083-470X
person.identifier.ridN-1908-2019
person.identifier.scopus-author-id7201895802
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication24ad7119-d61f-4bdb-a5d5-9bd6e2c37312
relation.isAuthorOfPublication.latestForDiscovery24ad7119-d61f-4bdb-a5d5-9bd6e2c37312
relation.isProjectOfPublicationbc618016-5a29-40a4-be00-d731e62339ef
relation.isProjectOfPublication.latestForDiscoverybc618016-5a29-40a4-be00-d731e62339ef

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